Something That Has Been "Bugging" Me: The Truth About Methicillin-Resistant Staphylococcus aureus (MRSA)

There has recently been an inordinate amount of press coverage about methicillin-resistant Staphylococcus aureus (MRSA) or “MERSA” as it is called on my local nightly news. As a card-carrying microbiologist, I think that it is great that the American public is finally learning about multidrug resistant bacteria and the serious public health threat that these bacteria pose. For those of you who don’t know, the incidence of MRSA (and other multidrug resistant bacteria) has been steadily rising since the early 1990s –mostly in healthcare and hospital settings (not in the general population). Not surprisingly, the recent media focus on MRSA has resulted in a lot of misinformation about MRSA strains. For example, every MRSA news clip that I have seen in past week has a school janitor in a mask, gloves and laboratory coat feverishly washing walls, desks (and even toilets) at the schools where MRSA-infected students and staff have identified. I can’t help but chuckle (after I get righteously indignant) when I see these clips because S. aureus (whether it is methicillin resistant or not) is an opportunistic pathogen that is transiently carried in the nasal passages of over 50% of all Americans! Contrary to popular belief, S. aureus does not survive for long periods outside of the human body. That said, school janitors can scrub as much as they want but they will not eliminate the natural reservoir of the organism which is the students and staff who work at the schools! Further, the organism, although infectious, is not easily transmitted from person to person–it requires direct and intimate personal contact in order for that to occur. Also, just because the organism is resistant to methicillin it doesn’t mean that there are no other antibiotics that can be used to treat MRSA infections. In fact, if diagnosed early and correctly, MRSA infections are easily treated. So, why is the news media making such a big deal about MRSA? Continue Reading...

More Problems in Pharma Land: GlaxoSmithKline Announces Job Cuts, Amgen's Profits Fall and Lilly's Potential Blockbuster Hits Some Bumps

A sharp drop in sales of its blockbuster diabetes medication Avandia has forced GlaxoSmithKline (GSK) to embark on a major cost cutting campaign that includes job cuts. It is not clear where the cuts will take place or how many jobs will be lost. The company said it would close some of its manufacturing plants, including a plant in Puerto Rico which employs around 900 workers and has been a target of regulatory scrutiny because of ongoing quality control issues.

Although this is the first official public announcement of layoffs at GSK, my inside sources tell me that several hundred employees have already lost their jobs at GSK’s Collegeville, PA facility.

GSK’s announcement coupled with a sharp drop in Amgen’s third quarter profits and Lilly’s problems with clinical development of prasugrel (its highly anticipated anti-clotting drug) indicate that the road will be rather bumpy for the biopharmaceutical sector in the near future.

Until next time…

Good Luck and Good Job Hunting!!!!!!!!!

BioInsights Website Update: Failure to Launch!

For those of you who don't know, BioJobBlog is powered by my company, which is called BioInsights.  Unfortunately, the BioInsights website redesign (that I announced in a post over the summer) has encountered a number of unforseen problems.  These include:  the web hosting service that housed the site going out of business and problems with backup files that contained the redesigned site.

Although GoDaddy is now hosting the old website (which is up and running), I recently learned that the website migration process disrupted e-mail service at the site.  I am pleased  to announce that the e-mail problems have been resolved and you can begin to fill up my inbox again!

I am planning to launch the new and improved BioInsights website some time in January, 2008.  I am keeping my fingers crossed.... Ah, the Internet...it's a beautiful thing!

Until next time....

Good Luck and Good Job Hunting!!!!!!!!!!

Another Pfizer Misstep-Let's Offer 'Em Relocation

There was a piece posted at TheDay.com entitled “More Pfizer People Opting to Transfer to Groton-New London”. The gist of the post was that Pfizer offered relocation packages to about 1,000 out-of-state and overseas employees a transfer to Connecticut earlier this year. Pfizer HR officials expected fewer than half of them to accept the offer. Instead, about 70% of the employees decided to accept the offer—much to the company’s chagrin. Apparently, working for Pfizer in Connecticut was a better option than having no job at all in the Midwest, Europe and elsewhere. The thing that puzzles me is why Pfizer thought otherwise. Maybe the folks who thought Exubera would be a blockbuster came up with the “nobody will want to live in Connecticut so let’s offer it to them anyway strategy!”

Unlike the rest of the US, I bet the housing market is booming in Groton-New London. Can you think of a better place to live that Southeastern Connecticut?

Until next time….

Good Luck and Good Job Hunting!!!!!!

Medical Device Manufacter Boston Scientific Sheds 2,300 Jobs

Not to be outdone by big pharma, Boston Scientific, the medical device manufacturer that specializes in metal and drug-coated stents (which have recently garnered their fair of negative publicity in cardiovascular circles) anounced that it would be cutting about 2,300 jobs or 8% of its workforce.  The company did not specify exactly which employees would be laid off but it expects to save about $500 million dollars after the job cuts take effect.

Boston Scientific's recent acquisition of Guidant coupled with weakness in its core stent franchise has saddled the company with $8 billion in debt.  In addition to the job cuts, the company is “actively seeking buyers” for its actively seeking buyers for some of its business lines, including its cardiac surgery and vascular surgery businesses.

Until next time....

Good Luck and Good Job Hunting.....

More Bad Pharma News: Novartis to Shed 0ver1,200 Jobs

Ed Silverman who runs the  Pharmalot blog reported that Novartis is slated to cut about 1,200 jobs to save the company about $230 million a year.  According to the post at Pharmalot, Novartis will let 240 employees go at its US- based headquartersin Hanover, New Jersey and eliminate over 1,000 full time and contract sales representatives from its workforce.  Also reported was that Novartis is planning to create a biologics division within the company.  I find this extremely interesting because Novartis already has a strong footprint in the biologics biz  via its wholly-owned subsidiary Sandoz, which is one of the market leaders in the follow-on biologics aka biosimilar sector.

I guess having a biologics division is de rigueur these days if you are a big pharma company.  I am still wondering why it took so long for all of these high paid pharmaceutical executives to figure out that biotechnology was the next  big thing?  You would think that after 30 years, they would get the hint.  But then gain these are some of the same people who brought us Vioxx, Avandia, Exubera and ...go ahead ....pick your favorite.

Until next time....

Good Luck and Good Job Hunting!!!!!!!!!!!!!!! 

Can Anything Else Go Wrong at Pfizer?

First, there was the torcetrapib catastrophe and now the Exubera debacle. Pfizer announced late yesterday that it would stop selling Exubera, the first approved inhaled insulin product, less than two years after its approval. Despite heavy promotion by Pfizer, Exubera sales were tiny, with prescriptions amounting to less than 1% of the multi-billion dollar insulin market.

Once heralded as a potential blockbuster drug by industry analysts, Exubera was plagued with questions about its safety, efficacy, convenience and cost. The bottom line is that it worked no better than injected insulin and, results from clinical trials showed that Exubera could decrease patients’ breathing ability. This coupled with the appearance of the delivery device, which resembled a bong (not that there is anything wrong with that), contributed to the inability of Exubera to gain acceptance among patients and physicians.

Exubera was originally developed by Nektar, a small publicly traded California-based biotechnology company that specializes in inhalation technology and protein delivery systems that include PEGylation. Pfizer bought the marketing rights from Nektar and assumed responsibility for clinical development of Exubera.
Continue Reading...

Social Networking for Physicians and Drug Companies

It was only a matter of time before physicians jumped on the social networking bandwagon—not that there is anything wrong with that. Sermo, founded in September 2006 in Cambridge, Mass., provides a forum for doctors to seek diagnostic advice from peers. The site earns money by letting clients such as hedge funds monitor doctors' anonymous conversations and thus gain insight into, say, the popularity of certain medications and treatments. Sermo rewards physicians whose input is highly ranked by other members and soon will offer to pay doctors for participating in its clients' surveys.

Late last week,Pfizer inked an advertising and promotional partnership deal with Sermo. Facing financial pressures as some of its best-selling products lose patent protection, Pfizer is looking for more-efficient ways to reach the doctors who prescribe its medicines. Under the arrangement, Pfizer-affiliated doctors will be able to talk candidly with the site's 31,000 members, potentially giving the company insights into prescribing patterns and a way to show doctors data on its drugs.

Pfizer said it plans to discuss the partnership with the FDA since it is the first drug company to do a deal with Sermo. Call me crazy, but I see an enormous conflict of interest here. Maybe officials at FDA will also see it—yeah right!

Until next time….

Good Luck and Good Job Hunting!!!!!!

Is Biogen IDEC Worth the Hassle?

Biogen IDEC hired Goldman Sachs & Co and Merrill Lynch & Co as their investment bankers late last week to find a buyer for the company after it put itself up for sale. Once this story broke, the names of the usual suspects–Pfizer, Sanofi-Aventis and Johnson and Johnson– were bandied about as potential buyers. Although Pfizer and Sanofi-Aventis desperately need to expand their biotechnology portfolios to remain competitive, the acquisition of Biogen IDEC makes little sense for either of the two companies. Pfizer is just too big and has spent the last five years trying to figure out how to reorganize its pipeline and what to do with all of the employees it inherited from its acquisition of Warner Lambert and Pharmacia in the 1990s. Sanofi-Aventis has little experience in biotechnology and has no real expertise in neuroscience. J & J which already has a big biotechnology presence in Ortho Biotech (Procrit) and Centocor (Remicade) may be looking to expand into the neuroscience realm.

Although Biogen IDEC may be a better fit for J & J than Pfizer or Sanofi-Aventis, the rights to Biogen IDEC’s two best selling products, Rituxan and Tysbari, are co-owned by Genentech and Elan respectively. To complicate matters, Genentech and Elan both have the right to buy Biogen’s rights to the drugs if ownership of the company changes. To that end, Genentech has both the resources and the motivation to gain complete control of Rituxan, one of its leading anti-cancer drugs. The outlook for Tysabri, a treatment for multiple sclerosis which has been plagued by safety problems is still unclear and Avonex, another treatment for MS, has been steadily losing market share for the past few years. Because sales of Rituxan are what are driving Biogen IDEC’s current growth, the loss of the rights to this product would severely diminish the company’s value to prospective buyers.
Continue Reading...

Biogen IDEC For Sale?

Biogen IDEC, one of the world's largest and most profitable biotech companies, may be for sale.  The company was approached  last week by several pharmaceutical suitors and Carl Icahn the billionaire former corporate raider.  Mr Icahn has been interested in getting into the biotechnology business in a big way ever since he donated a large sum of money to Princeton University  (his alma mater) for a new molecular biology building. He currently owns substantial shares in a number of companies including Imclone, Biogen IDEC and others.

Biogen IDEC officials announced that while they are happy with the company's direction, they wanted to explore whether an acquisition by  a major pharmaceutical company may result "in superior value in the current environment". At $81 per share the company is valued at over $23 billion.  So, acquisition of the company would be the biggest ever of a biotechnology company and would easily eclipse the $15.6 billion that AstraZeneca paid to buy vaccine manufacturer MedImmune  last year.

Stay tuned for more updates!

Until next time....

Good Luck and Good Job Hunting!!!!!!!!!!

The Genentech Conundrum: Profits or Access to Medications?

Biotech giant Genentech is moving towards restricting the use of its cancer drug Avastin to treat wet age-related macular degeneration (WMD), the most common cause of blindness in the elderly. Currently, many ophthalmologists use Avastin to treat WARMD even though it was not approved by the US Food and Drug Administration (FDA) for that indication. For those of you who may not know, physicians who are licensed to practice medicine in the United States are permitted to use approved medications to treat any disease or condition if they believe that the medication is in the best interests of a patient.

Genentech said it is restricting Avastin use because it recently won approval for a new drug called Lucentis to treat WARMD. Many ophthalmologists started using Avastin (which has the same mechanism as action as Lucentis) before Lucentis won approval from FDA in June 2006. The New York Times reports that Lucentis is being used to treat 55 percent of new patients with WMD and Avastin accounted for most of the rest of the patients — or nearly half the market.

From a medical and regulatory standpoint, Genentech is justified in restricting the use of Avastin to treat WMD because it was not approved for that indication. Further, promoting or encouraging off-label use medications is a big regulatory no-no! Nevertheless, many ophthalmologists suspect that business rather than medical reasons are what is driving Genentech’s decision to restrict the use of Avastin—Lucentis costs about $2,000 per dose whereas Avastin only costs $50 per dose.
Continue Reading...

More Product Recalls at Wyeth

The news from Wyeth gets more and more interesting every day.  It was reported today that Wyeth intends to follow in the steps of Johnson & Johnson and pull its baby cold medications off the market over industry concerns that some caregivers are misusing the drugs, resulting in accidental overdose.

A Wyeth spokesman reported that the company will stop making Robitussin Infant Cough DM Drops, and will recall two products it discontinued last year, Dimetapp Decongestant Plus Cough Infant Drops and Dimetapp Decongestant Infant Drops. Wyeth also plans to place a warning on its other cold medications advising they should not be used on children under two years of age.

Until next time...

Good Luck and Good Job Hunting (not at Wyeth...)

Just in the Nick of Time: Pfizer Recognizes Biotech' s Potential

Pfizer announced earlier this week that is will establish a biotechnology research and development center in the Bay area in the near future. I think that it 's about time that the world’s largest pharmaceutical company finally realized that its future growth and success no longer lie exclusively in the realm of small molecules–duh!!!! I ask–“Where have Pfizer executives been and what have they been doing for the past 20 years"? I guess they subscribe to the old adage; “better late, than never”. Tell that to all of the right-sized Pfizer employees who lost their jobs in the past few years.

Maybe Pfizer is on-track and will get it right this time. One can only hope!

Until next time….

Good Luck and Good Job Hunting!!!!!!!!!!!!

Rumor Has It...........

I recently participated in a career development recruiting event where I had the opportunity to chat with folks involved with career development for PhDs and postdoctoral fellows at a major NYC university. Not surprisingly, they confirmed my observation that the job market for PhD-level scientists is not a good one. After several spirited discussions, we all agreed that systemic changes must occur at the graduate school and federal granting agency levels to reduce the number of PhDs that are minted each year to insure that extant PhDs may actually find employment after they complete their training. That said, somewhat to my surprise, I learned that there is a growing demand for Masters level students in the private sector. Apparently, hiring managers at biotech and pharma companies are finally realizing that undergraduates with basic science training and a smattering of postgraduate work either in business or biotechnology (or both) can bring real value to their companies. Continue Reading...

Amgen Cancels Plan to Build a New Biomanufacturing Facility in Ireland

Not unexpectedly, Amgen Inc  said on Wednesday it had shelved plans for a production plant in southern Ireland which would have generated 1,100 jobs. Amgen said the decision to postpone indefinitely the building of the factory in County Cork was "based purely on developments relating to Amgen's global business" and was no reflection on Ireland. As many of you may know, Ireland in recent years has become a hotbed of biomanufacturing largely because of its skilled workforce and lower cost structures.

In a statement, the company said it would keep the site on which the new plant -- intended mainly to supply the European market -- was to be built. Amgen, whose business has been affected by tighter regulatory restrictions on drugs, has embarked on a cost-cutting programme that includes reducing its global workforce by up to 14 percent.

Plans for the Cork facility were announced last year. It had been expected to be operational by 2012.

Until next time,

Good Luck and Good Job Hunting!!!!!!