Are Scientists Really Dull?

Bruce Charlton, a professor of theoretical medicine at the University of Buckingham and Editor in Chief of the journal Medical Hypotheses recently published in Oxford magazine and his blog a provocative and controversial article entitled “Why Scientists Are So Dull”

The article, which caused a firestorm in the UK was crafted to get the scientific establishment to rethink its parochial approach to scientific training and career development for young scientists. Because of the blunt nature and in-your-face tone of the article, Dr. Charlton may have alienated some would-be supporters who unfortunately failed to see the intended humor and call-to-action of the article. Unfortunately, in my experience, the public perception of scientists is consistent with Dr. Charlton’s claim—that, we as a group, are dull.

Throughout my career, I have routinely been asked by non-scientists (after meeting them in social situations) “You’re not really a scientist—are you?” Invariably, they say something like “You are too funny and too much of a character to really be a scientist.”

I know that stereotyping is inherently dangerous and wrong, but stereotypes usually originate from commonly observed, shared characteristics (traits) exhibited by members of a particular group of people. That said, maybe it is time for us to let the lay public know that not all scientists are dull, “eggheads” types and that many of us are very insightful, creative people. In my opinion, the only way for us to lose the ‘dull’ moniker is to publicly promote the importance and creative aspects of science whenever we can. To that end, it is time for us to log off of our computers, leave our laboratories and let the world know that—contrary to public opinion—we aren’t DULL people!!!!

Until next time…

Good Luck and Good Job Hunting!!!!!!!

 

Does Eating Turkey Really Make You Sleepy?

For those of you who want an answer to this age old question, check out this post at the What’s New In Science Research blog.

Personally, I only feel tired after eating turkey on Thanksgiving….maybe my sleepiness has more to do with overeating and excessive drinking rather than anything to do with turkeys?

Happy Thanksgiving!!!!!

 Until next time.....

Good Eating and Good Napping!!!!!!!

 

FDA Delays Approval of Ceftobiprole to treat MRSA

U.S. regulators have delayed a decision on approval of an antibiotic from Johnson & Johnson and Basilea saying they need further audits of clinical sites, the two companies said on Wednesday.

Ceftobiprole, a broad-based spectrum antibiotic targeted mainly against infections caused by methicillin-resistant Staphylococcus aureus (MRSA), is Basilea's lead product and the news hit the Swiss biotech shares, which plummeted 27 percent.

In a so-called complete response letter on the drug's approval application, for complicated skin and skin structure infections, the Food and Drug Administration (FDA) said it was unable to review the clinical data submitted with the NDA until issues of data integrity had been resolved. The FDA has asked J&J to conduct additional audit work of clinical investigator sites and to address specific questions related to site monitoring."

Ceftobiprole is approved in Canada and Switzerland and has been recommended for approval in the European Union. A new application in the United States is planned within a year.

Late last week, FDA rejected an NDA for another antibiotic, iclaprim, being developed by Arpida, another Swiss company. It has been a bad two weeks at FDA for approval of new antibiotics—drugs that we desperately need.

Until next time….

Happy Thanksgiving

 

Scientists and Social Networking

I first thought about starting a social network for life sciences professionals about a year ago after joined I Facebook and LinkedIn and then learned about SciLink, one of the first social networks for scientists. Apparently, others had the same idea and today, there are currently, by my reckoning, no fewer than 20 social networks for scientists—each promoting a unique approach to networking for scientists.

David Bradley, a UK-based science writer who can be followed on Twitter as sciencebase, did me a favor by posting a piece oh his blog in early November that reviews many of these networks. Surprisingly, most of them were designed almost exclusively for academic scientists! I was thrilled to learn this because we created BioCrowd , our new social network, for ALL life science professionals not just academicians and industry scientists. David has graciously agreed to allow me to repost his article entitled "Social Media for Scientists" below.

Social Media For Scientists

Towards the end of October, I received a flurry of emails asking me to check out new social networking sites for scientists, I’ve already reviewed the nanoscience community, of course. I suspect that, the academic year having moved into full swing, there were a few scientists hoping to tap into the power of social media tools and the whole web-two-point-ohhhh thing.

This from Brian Krueger:

“I came across your blog during my weekly Google search for “science social network.” I thought you might be interested in my website, LabSpaces.net. It’s a social network for the sciences that I’ve had on-line for the last two years and I recently got my University to send out a press release about it. I think you should stop by and check it out. Let me know what you think, I’m always looking for suggestions on how to improve the site.”

LabSpaces has all of the features of a social-networking site with the addition of a daily science newsfeed, lab profiles, a science forum, blogs, and a science protocol database. Apparently, the site provides space for researchers to create their own user profile, add their publication history, upload technical research protocols, blog about science, and share research articles with the community. The site will soon host a free video conferencing service to facilitate long distance collaborations and journal clubs.

New Zealander Peter Matthews who works in Japan emailed:

“I am a full-time researcher from NZ, working in Japan, at a museum with many international research visitors. This multilingual environment made me very aware of: (1) the difficulties that non-English based researchers face when using English, and (2) the difficulties that English mono-linguals face when trying to access or publish research in other important research languages, such as Spanish, Chinese, Japanese, French, and so on. Hence my website: The Research Cooperative - http://cooperative.ning.com. Please have a look, join if you want, and please tell any friends and colleagues about this site if you think they might find it useful.”

Pascal Boels, Managing Director of SurgyTec.com emailed with a medical tale:

“Our website is for and by medical professionals. It’s a video-sharing site for surgeons and medical professionals to show off their newly minted skills. It makes it easy for medical professionals to upload videos or slideshows and share those with the community. You can search for videos by specialty, organ/region, tissue, etiology, operation type, or technique. Many surgeons perform original and high-quality techniques in their operating room and equally many surgeons would like to learn from these new and inspiring techniques. Up till now it was very difficult, time consuming and expensive to take a look in each others operating room and share practical knowledge, tips and tricks. Surgytec.com provides the solution for this problem. We are currently serving over 4000 surgeons from more than 124 countries, sharing over 400 procedures

Priyan Weerappuli had long been interested in scientific research but felt that applied research was guarded by private institutions while basic research was held within the confines of colleges and universities by overpriced journals and an oversimplification that occurred whenever research results were translated for more general audiences. His forum/platform will attempt to open this research to a general audience - http://www.theopensourcescienceproject.com

Some correspondents are claiming they’re approaching web 3.0 nirvana:

“ResearchGATE is proud to announce a major update: We greatly improved our search functionality and called it ReFind. The name symbolizes the importance of an efficient and result-driven search functionality within research in general and within our network in particular. ReFind is one of the first search engines based on semantic, “intelligent” correlations. It enables you to find groups, papers, fellow researchers and everything else within and outside of ResearchGATE without having to read through dozens of irrelevant results. Just type a few sentences into ReFind or simply copy and paste your abstract. Our semantic algorithm will then search the leading databases for similar work, providing you with truly relevant results.” [Sounds like my Zemanta/ResearchBlogging.org idea, DB]

One observer pointed out, however, that ResearchGate’s semantic search is maybe not the greatest thing to happen to search in a decade (especially, when we have the likes of True Knowledge Ubiquity, and Zemanta. Indeed, some users have said it is not much of an improvement on conventional search.

Then there was:

“ScienceStage.com - Science in the 21st century - A wide forum for science - on an interdisciplinary, international and individual level. ScienceStage.com, the only universal online portal for science, advanced teaching and academic research, bridges a major gap in scientific research and learning. ScienceStage.com is a virtual conference room, lecture hall, laboratory, library and meeting venue all in one.”

But, perhaps the best is saved for last. An Oxford graduate student, who has completed his PhD, Richard Price, has launched Academia.edu, which he says does two things:

“It displays academics around the world in a ‘tree’ format, according to which institution/department they are affiliated with. And, it enables researchers to keep track of the latest developments in theirfield - the latest people, papers, and talks.”

Price wants to see every academic in the world on his tree and already has Richard Dawkins, Stephen Hawking, Paul Krugman, and Noam Chomsky as members. But, that’s the hype what about its potential? It resembles BioMedExperts because both use a “social” publishing tree, but is that enough to engage scientists?

It will be interesting to see whether any of these sites gain the traction their creators hope for and how things will pan out as the credit crunch bites harder. “There are a bunch of them out there,” Krueger told me, “It’s kind of scary how many came out after Nature and I went on-line in 2006. There’s definitely a lot of competition out there, it seems like a new one appears every month. I wonder how the economy and loss of tech funding is going to affect the larger start-ups.”

Then, there are those perhaps more well-known social media sites and networks for scientists, that are listed in no particular order:

Nature Network - uber network from the publishing giant

BioMedExperts - Scientific social networking

BioWizard - Blogged up Pubmed search

Mendeley - Digital paper repository and sharing

Labmeeting - Ditto

YourLabData - socialised LIMS

SciLink - Sci-Linkedin

Myexperiment.org - mostly workflows.

Laboratree.org similar to Researchgate. Not particularly social beyond groups and sharing documents with collaborators, but email is better, and arguably more secure.

scitizen.com - collaborative science news publishing

SocialMD - Med-Linkedin

Ozmosis - Ditto

DNA Network - network of DNA/genetics bloggers

ResearchCrossroads - Socialised grant databases

MyNetResearch - Socialised LIMS at a price

SciVee - YouTube for scientists (see also Watch with Sciencebase page

Scientist Solutions - science chat

There are so many, I can barely keep up, but if you have any you think I should add to the list, let me know via the comments box below. Or, more importantly, if you have used any of these systems please leave your thoughts.

Meanwhile, my apologies if you were expecting a lesson in how to use the likes of Twotter, FiendFreed, Ding, Pyuke, or Facebok’s feeble science apps, to help you get on in science socially, but I thought it was about time I did some linking out to the web 3.0 brigade in the world of science, so here they are.

Addendum: Since David published this piece in early November, BioJobBlog learned about several other social networks for scientists including labroots, beaker, scientistsolutions and wizfolio.

Until next time…

Happy Thanksgiving!!!!!!!!

 

The Dark Underside of New Jersey Dog Breeders: Grace Abrams Strikes Again

I heard today from another one of Grace Abrams’ grifting victims. Apparently, this individual purchased a sick puppy from Ms. Abrams several months ago which at one year old developed some problems that likely resulted from congenital defects due to inbreeding. This person told me that a friend of hers also purchased a ‘Havanese” from Ms. Abrams which they suspect really isn’t a Havanese (despite ‘papers’ that indicate that it is). As you may recall, we also received suspect pedigree papers for the dogs that we purchased from Ms. Abrams (which prompted us to get both dogs tested). I sent Grace’s most recent victims information on the Wisdom Panel DNA tests that we used to perform genetic testing on our dogs, the results of which confirmed that Moose, our so-called Havanese, was really a mixed breed dog!

I wonder how long it will take Donna Roberts to send me one of her threatening, vitriolic notes  (read the comments) after I post this story?  I will keep you posted….

Until next time…

Good Luck with finding a new puppy!!!!!!!

Was the Dot-Com Bust Really a Bust?

The other day I was chatting with Tony Stubblebine of CrowdVine (the social networking company building BioCrowd for us) and I was lamenting the possible burst of the social networking bubble before BioCrowd is launched. Tony reassured me and said that “Everyone thinks that after the dot-com bubble burst that almost all Internet-based businesses failed. However, when you look more closely, you will find that this simply isn’t true—there were many survivors who were able to build robust business as the Internet matured.”  While I felt a bit better after hearing that (Tony generally knows what he is talking about) I wasn’t totally convinced that he was right. After all, I am one of his customers who are building a new social network. That said, the very next day after my chat with Tony, I found an unusually. insightful article in the New York Times entitled “Lessons of Survival, From the Dot-Com Attic.”

The authors of the article suggest that based on their analysis of existing data that 48% of dot-com companies founded in 1996 were still in business in 2004 (more than four years after the Nasdaq’s peak in March 2000 and the so called dot-com bubble burst). According to the authors, “most people are stunned by this figure: they tend to guess that about 90% of the companies failed.” Further they suggest that “the dot-com survival rate is as good as or better than that for technologies like automobiles, tires and televisions during their formative years.”

How did the dot-com survivors do it? Instead of trying to a make a big splash in high profile market sectors, they identified niche markets that didn’t offer ROIs of hundreds of millions of dollars returns but represented viable Internet-based, business opportunities that could flourish if nurtured correctly. This largely assuaged most of my concerns about a possible impending social network bubble bust and proved to me that Tony knows his stuff! So, whether or not the social network bubble is going to burst, BioCrowd will be launched and we hope that like any new member of a species that it will be strong and fit enough to survive! 

Until next time.

Good Luck and Good Job Hunting!!!!!!!

 

 

How to Keep Your Job Whether or Not We're in a Recession

Over the past few weeks, I have seen many posts on various career and job blogs offering people advice and tips on how to hold on to their current jobs. In my opinion, most of these posts didn’t offer any new or insight tips on this topics. Instead most of the suggestions were obvious and rather pedestrian. For example, be pleasant to your boss, show up on time, don’t leave before the official work day ends, volunteer to take on new projects yada, yada, yada.

While these suggestions may help to some extent, I think that the best way to keep a job is to think strategically and learn how to manage it to your maximum benefit regardless of prevailing economic conditions. In other words don’t wait until you are in a precarious situation to become a model employee. With this in mind, I came across an extremely insightful article on job retention in the business section of today’s NY Times.

The author, who has been a practicing psychologist for 22 years and a “boss” for the past couple of years, provides insights on job retention from both employee and managerial perspectives. I highly recommend that you read this article—even I learned a thing or two!!!

Good Luck and Good Job Hunting (hang on to your current one if you can—its tough out there)!!!!

 

 

BioCrowd-Beta Is Ready For Launch

I want to let my readers know that a beta-version of BioCrowd is ready for review. For those of you who may not know about BioCrowd, it is a social network for life sciences students and professionals that was created by Vincent Racaniello a Professor at Columbia University College of Physicians and Surgeons and me. 

The reason we started BioCrowd was that Vincent and I both perceived a need for undergraduate and graduate students and postdoctoral fellows to more effectively network with established scientists and life sciences professionals to further advance their careers or find jobs. The social interactivity of Facebook and the business connectivity of LinkedIn are what led to the creation of BioCrowd.

We are looking for a few brave women and men who want to help to beta-test BioCrowd before we launch.  If you are interested, please visit us at www.biocrowd.com and drop us a line.   For those of you who don't want to participate at the moment, but want to learn about our progress, you can follow us on Twitter and FriendFeed ,

Until next time...

 

Good Luck and Good Job Hunting!!!!!!!

Using Twitter to Find That Next Job

I never truly understood the power and reach of Twitter until I caved in and started using it about a month ago. Over the past couple of weeks, I realized that Twitter is an ideal tool for networking and job hunting. Apparently, I am not alone. Miriam Salpeter from Keppie Careers has graciously agreed to shares some tips on using Twitter to help you search for a Job. Follow Miriam on Twitter @Keppie_careers

Tweeting Your Way to a Job

Would you believe that you can tweet yourself to a job opportunity 140 characters at a time? It’s been done! Statistics show that job search networking is much more effective when you make “loose” connections - touching base with people beyond your immediate circle whose networks and contacts are much different from your own. With over 3 million users, Twitter offers an unparalleled opportunity to create an extended network.

Not convinced that Twitter is actually a high-powered job search tool? Read on to learn how Twitter can uniquely position you for job-hunting success!

What Can Twitter Do For You?

  1. Afford access to other professionals in your field. When you follow industry leaders, you’ll know who spends time with them, what conferences they attend (and what they think of the speakers!), what they’re reading and what is on their minds. This is great information to leverage for your search.
  2. Provide exposure and credibility as well as personal and professional relationships when you connect to others in your industry.
  3. Offer you a venue to demonstrate your expertise and share information in quick, pithy bursts of wisdom. This is perfect if you don’t have the time or energy to create a blog.

Unique Aspects of Twitter

  1. It is casual and immediate and a great place to “meet” informally.
  2. You’ll find an array of people on Twitter, including CEOs, top-level executives, hiring managers, recruiters and everyone in-between! It’s one-stop shopping for your networking needs. You’ll be surprised to find that stars in your field (mentors) may follow you if you reach out to them!
  3. Unlike Facebook, where it is kind of creepy if you start trying to “friend” people who are connected to your contacts, it is acceptable (and expected) to follow people on Twitter because another friend or colleague does.
  4. It forces you to be brief. Coming up with your “Twit-Pitch” - what you have to offer in 140 characters or less - will help you clarify your value proposition. Remember: less is more!

 

Continue Reading...

FDA Advisory Panel Rejects another NDA for a New Antibiotic

A Food and Drug Administration (FDA) advisory panel Thursday rejected a proposed antibiotic by Arpida Ltd. (ARPN.EB) to treat serious skin infections, a Food and Drug Administration spokeswoman said. The rejection was expected because results from Phase III clinical trials showed that patients taking iclaprim (a trimethoprim-like antibiotic) had lower cure rates than Pfizer's Zyvox (linezolid) which was used as a comparator antibiotic in the studies.

The panel voted 17 to 2 against a question that asked whether the data presented demonstrated the safety and effectiveness of iclaprim for the treatment of skin infections. Although FDA isn’t required to follow the advice offered by its advisory panels, the agency typical follows the panels’ recommendations. This means that it is unlikely that FDA will approve iclaprim to treat complicated skin and soft structure infections (cSSIs).

This is bad news for Arpida Ltd, a small, Swiss biopharmaceutical company and Americans with cSSIs infections that are caused by  multiple drug resistant bacteria.

Until next time…

Good Luck and Good Job Hunting!!!!!! 

More Job Cuts and Plant Closures at Pharma Companies

Astra Zeneca announced today that it would cut 1400 jobs and close several manufacturing facilities worldwide. According to a post on the Pharmalot blog “about 600 full-time jobs will be lost in Sweden as packaging operations are expanded in Wuxi, China. The cuts will come on top of the 7,600 positions the drugmaker plans to eliminate by 2010. The plant closings will occur in Spain, Belgium and Sweden by 2013. Manufacturing jobs will also be trimmed in Sweden and the UK as production is shifted to lower-cost countries in emerging markets.”

On Tuesday Wyeth disclosed that it was eliminating 70 positions at its Pearl River, New York, facility (which employs 3,200 workers, 118 employees at its Rouses Point facility in upstate New York that employs 725 people work, and 124 jobs at its Sanford, North Carolina manufacturing facility. Ironically, as more and more US workers are laid off, many big pharma companies like Merck, Pfizer and GlaxoSmithKline are expanding operations at their research facilities in India. In fact, Merck is doubling its headcount from 800 to 1,600 employees at its research facility in India that was opened a little over a year ago.

Until next time…

Good Luck and Keep on Looking!!!!

 

Federal Trade Commission to Hold Roundtable on Follow-on Biologics--Is There Really Anything Left to Talk About?????

The Pharmalot blog reported today that this coming Friday, the US Federal Trade Commission (FTC) will conduct a workshop on the issue of follow-on biologics. The roundtable will apparently be organized into five panels to discuss: 1) the price and market share effect of entry by both biosimilar and biogeneric drugs, 2) the likely competitive effects of reference product regulatory exclusivity, 3) biotechnology patent issues, 4) the likely competitive effects of follow-on biologic regulatory incentives, and 5) the patent resolution process.

The first thing that comes to mind is “beating a dead horse” (euphemistically of course). Call me crazy but these very issues have been bandied about and discussed ad nauseum and  for the past decade or so. I am not sure what new revelations will come to light at this Friday’s FTC roundtable meeting. 

Here’s a thought. Maybe industry representatives, FDA regulators and the insurance companies ought to ask the European Union how they were able to craft their version of a regulatory pathway for approval of these products way back in 2004. Nah…let’s let the lobbyist duke it out and see which side wins!

Until next time…

Good Luck and Good Job Hunting

 

Dealing with 'Back-Stabbing' Co-Workers and Colleagues

Do you know somebody at work who is friendly, agreeable and even solicitous— who will smile to your face—and then say bad things “behind your back” to your boss and colleagues? I suspect that everybody has encountered one or more of these politically ambitious individuals at some point in their careers. In most cases, everybody in the office, laboratory etc knows who these people are but are ill-equipped to effectively minimize the damage that they may cause. I highly recommend reading this article that I found today to begin to learn how to manage these troublesome co-workers and colleagues.

Until next time…

Good Luck and Good Job Hunting!!!!!!!!!!

Some News from Down Under: A Map of the Kangaroo Genome

Researchers at the ARC Centre of Excellence for Kangaroo Genomics (KanGO), including University of Melbourne, ANU, WEHI, University of Sydney, University of UNSW and the Australian Genome Research Foundation (AGRF) announced today (yesterday in Oz) that they have built a framework to assemble the genome of a model kangaroo, the tammar wallaby.  DNA sequence data obtained by the Australian Genome Research Facility (AGRF) with funding from the Victorian government will be arranged using the genome map.

KanGO Director Prof. Jenny Graves said “Australia’s weird and wonderful animals are making crucial contributions. The kangaroo has helped to consolidate Australia’s reputation in this important genomics era,” More importantly the map and DNA sequence may open up new areas of research into how genes are turned on and off during development of all mammals.

Those Aussies…you gotta love ‘em!

 

FDA is Taking Some Heat....Again

An article in today’s New York Times reports that several FDA scientists have accused the agency of granting market approval to several unsafe medical devices. According to published reports, “the House Committee on Energy and Commerce will investigate the accusations, first aired when eight agency scientists wrote a private letter in May to FDA commissioner Andrew von Eschenbach.”

Unfortunately, the allegations made by the eight scientists against the agency are nothing new. Frequently, agency managers (and sometimes political appointees) lean toward approving drugs or devices when the data pertaining to efficacy and safety are equivocal.

My sources at FDA suggest that this is what happened with approval of Merck’s ill-fated pain medication Vioxx.

Recently, there has been a spate of safety claims made against medical devices manufacturers. This is not surprising because the regulatory hurdles for marketing approval of devices are much lower for devices as compared with drugs and the medical devices and diagnostics business is the fastest growing sector in the life sciences. For an overview of the medical devices and diagnostics industry please read my recent article published in Science Careers.

Hopefully, new leadership at the agency will turn things around!!!!!!!

Until next time…

 

Good Luck and Good Job Hunting!!!!!!!!

.

 

Outsourcing Pharmaceutical R&D

As you all know by now, American pharmaceutical companies have been intermittently laying off thousands of employees for the past two years or so. Many of the employees who have lost their jobs are R& D scientists, marketing personnel and sales representatives. This seemingly makes sense—because fewer drugs are being discovered and brought to market, fewer people are required to market and sell them. That said, isn’t discovering new drugs the currency and lifeblood of the pharmaceutical industry? How do these companies plan to stay in business if they continue to layoff employees who are seemingly responsible for developing new sources of revenue for them? Taking their cues from the IT and software industries, many US drug makers are beginning to either transfer R&D operations to foreign, company-owned research facilities or outsourcing some or all R&D activities to foreign contract research organizations (CROs).

For those of you who may not know, US pharmaceutical companies have been routinely outsourcing various aspects of R&D and drug manufacturing for many years. For example, a majority of the active pharmaceutical ingredients (APIs) and excipients found in many drug sold in the US are routinely manufactured in places like China, India and elsewhere. Until recently, many pharmaceutical companies were reluctant to outsource many critical R&D activities, e.g., screening, medicinal chemistry, pre-clinical testing, etc. for fear of inferior quality. However, the increasing costs of conducting US-based R&D coupled with a worldwide glut of American-trained, foreign scientists (who were unable or not permitted to find jobs in the US) has made the practice of outsourcing R&D operations less risky and more economically feasible. After all, many of the scientists who work in company-owned foreign research facilities or foreign-owned CROs were trained by American scientists who work at some of America’s pre-eminent academic and government research institutions.

From a business perspective, it makes complete sense that pharmaceutical companies might opt to transfer or outsource R&D operations to foreign countries—the quality is good and it is much cheaper! That said, don’t expect the price of pharmaceutical drugs to plummet anytime soon as more drug makers outsource or expand their R&D operations in foreign countries. Put simply, pharmaceutical companies are outsourcing R&D to cut costs, drive up stock share prices and insure financial growth by preserving the staggering product profit margins that they currently enjoy. Take Bristol-Myers Squibb (BMS) for example. Late last Wednesday, its CFO told a group of financial analysts and investors that the company plans on trimming $2.5 billion by 2012 from its operating budget through US job cuts and revamping operations. Shortly after the announcement, I read with amazement that BMS is expanding its R&D operations in Bangalore, India and that they are looking to hire no fewer than five new Department heads—America’s loss is India’s gain!

While outsourcing or expanding R&D operations in foreign countries at the expense of American workers may help the bottom line of many US drug makers, it will do precious little to reverse the decade-long, decline of America’s global competitiveness in science and technology.

Until next time…

 

Good Luck and Good Job Hunting (try India)!!!!!!

 

 

 

Sheding New Light on Office Politics

The mere mention of office politics makes me want to cringe. This is probably because I have never been politically motivated nor have I ever taken advantage of a co-worker to advance my career. Those who know me will tell you that I am a tell-it-like-it is kind of guy. And, I simply refuse to play the game to get ahead. That is probably why I am blogger/science writer and not a vice president or CEO of some company. Nevertheless, for those of you who are ambitious and driven, you will need to learn to successfully manage workplace politics because--you don't--you may wind up like me (not that there is anything wrong with that).

I came across a fascinating article entitled "The Win-Win Way to Play Office Politics" that I think sheds new light on the often vilified practice of office politics.  Read it--you may learn a thing or two!

Until next time...

Good Luck and Good Job Hunting!!!!!!!!!!! 

Job Watch: Which US Metropolitan Areas Have Had the Largest Number of Mass Job Layoffs So Far this Year?

If you were thinking East Coast cities you would be wrong. Think further west! You can view the top ten list here.

The old saying “Go West young man/woman” is no longer apt in this economy.

Until next time…

Good Luck and Good Job Hunting (there are still some out there)

 

All Things Twitter

I finally started using Twitter a couple of months ago and I think it is pretty cool. That said, I am still a neophyte and I have yet to master the intricacies and nuances of Twitter speak (why are tweets not called twits?—it was a rhetorical question).

I found an informative post entitled 'My Twittonary-Every Twitter Term and Tool I Can Find' on the Sitemasher blog that helps to clarify the Twitter lexicon and provides insights in the latest twittering tools.

BTW, you can follow me on Twitter at BioJobBlog and BioCrowd.

Until next time…

 

Good Luck and Good Twittering (or should that be tweeting?????)

 

Bristol-Myers Squibb Announces $2.5 Billion in Cuts and Layoffs

Bristol-Myers Squibb (BMS) made a presentation this morning at the Credit Suisse Healthcare Conference that showed the company plans on saving an additional $2.5 billion in “productivity initiatives.” According to its new CFO, the company plans to squeeze the savings out of “headcount and related costs” — which  likely means more downsizing and layoffs.  Rumors have it that these job cuts will take place by December 1, 2008 just prior to when employee bonuses are traditionally decided.

To make matters worse, the Pharmalot blog reported today  that "the drugmaker earlier this week sent a voicemail to employees saying a 2 percent cost of living increase will be given this year to those who are meeting or exceeding performance standards."  The announcement has lead to speculation among BMS employees whether or not the same ceiling will be applied to the bonuses and stock rewards handed to Bristol-Myers CEO Jim Cornelius and members of his executive team.

Heavy losses incurred  by its former CFO who "bet the store" on mortgage-backed securities coupled with the recent, highly publicized failure of Jim Cornelius to purchase ImClone (to gain complete control over the multi-billion dollar Erbitux franchise) suggests that the future of the company may be in serious jeopardy.

Until next time…

Good Luck and Good Job Hunting!!!!!!!

 

Is Tenure Obsolete?

I had many discussions with undergraduate students at the ABRCMS in Orlando last week who were interested in pursuing PhD degrees in the biomedical sciences. I felt that I had an ethical and moral responsibility as a former academic and career development professional to tell them that the job market for PhDs is not good and that it is likely to get worse over the next few years. These discussions prompted me to revisit the role and contributions of tenure to the lack of academic jobs in the US today.

As I stated in a previous post, systemic changes must be made to the current academic paradigm to increase the likelihood that PhDs will be able to find jobs at the end of their training. In that post, I suggested that abolishing tenure and replacing it with renewable, performance-based five year contracts may help to reduce the glut of jobless PhDs by freeing up a small percentage of new faculty positions every five years. While this approach has been tried at several academic institutions, it has been largely been deemed unsuccessful. That said, I came across a provocative article in today’s New York Times about a bold new tenure proposal put forth by Michelle Rhee, the new, 38-year old Chancellor of the Washington, DC school system.

Ms Rhee’s revolutionary proposal offers tenured teachers salaries raises of up to $40,000 per year to give up tenure. It is important to note she has not proposed to completely abolish tenure. Under her proposal, teachers would choose between two compensation options—the green or red plans. Salaries for teachers in the green plan would rise meteorically, nearly doubling by 2010, but they would have to give up tenure for one year, after which they would need a principal’s recommendation to keep their job or face dismissal. Teachers who choose the red plan would also get big pay raises but would lose seniority rights that allow them to bump more junior teachers if their school closes or is overhauled. Red plan teachers who are not hired by other schools would either have to take early retirement, a buyout or face eventual dismissal. I like her plan because poorly- or under performing teachers can opt to take the cash and then either drastically improve to keep their higher paying jobs or do nothing, get paid well for a year or two and then get fired.

While Ms. Rhee’s proposal may work at the primary and secondary school levels, it likely would not be effective at the college and postgraduate levels, where salaries vary widely and are largely grant driven. Instead, I propose that tenure-for-life should remain intact at these institutions but be replaced with a “for cause” tenure review system. This system is tried and true and similar models have been successfully used for over 100 years by employers and labor unions. In this model, management and its unions agree upon the job responsibilities and performance metrics for individual that must be met each year, e.g. an annual performance review.  If a person is under performing or fails to meet his/her performance metrics, an employer can attempt to dismiss the employee “for cause” reasons.  However, before a dismissal for cause can occur, the employer must convince a judge or arbitrator in a hearing that the employee in question has violated the “dismissal for cause” provisions.  Because an employer must prove that an employee has violated the provisions that constitute for cause dismissal, the “for cause” claims against individual employees must be fastidiously documented and vigorously substantiated. This prevents employers from arbitrarily firing employees who are either outspoken troublesome or disruptive. According to my wife, who has been a union-side labor lawyer and union representative for 20 year, this system works well because the players (management and unions) all understand, abide by and play according to the rules of the game.

So what are some of the performance-based “for cause” metrics that I think ought to be considered for yearly evaluations of tenured professors? They are not much different than those currently used to adjudicate tenure decisions. That said, I propose the following five categories: 1) teaching, 2) publication record, 3) grant support, 4) institutional service and 5) commitment to innovation. In my opinion, adoption of the “for cause” tenure review model would help to do two things: improve the overall performance of tenured faculty members and provide newly minted PhDs and postdoctoral fellows with regularly occurring new job opportunities.

Until next time…

 

Good Luck and Good Job Hunting!!!!!!!!

 

 

 

New Technology: Using Google to Track the Flu

No matter what you may think of Google, you gotta love the brilliance and innovative moxy of the guys who run that company. In today’s New York Times, there was a story about a new web tool called Google Flu Trends. This tool is being evaluated as a new early warning system for fast-spreading flu outbreaks in the US.

Tests of Google Flu Trends, suggest that it may be able to detect regional outbreaks of the flu a week to 10 days before they are reported by the Centers for Disease Control and Prevention (CDC). It works by tracking and quantifying number of Americans who enter search phrases like “flu symptoms” into Google and other search engines. By analyzing these searches as they come in, Google Flu Trends creates graphs and maps of the country that show where the flu is spreading.  For example, in early February the CDC reported that the flu cases had recently spiked in the Mid-Atlantic States. But Google says its search data showed a spike in queries about flu symptoms two weeks before the CDC report was released.

According to public health experts “The CDC reports are slower because they rely on data collected and compiled from thousands of health care providers, labs and other sources. The Google data could help accelerate the response of doctors, hospitals and public health officials to a nasty flu season, reducing the spread of the disease and, potentially, saving lives.” Researchers have long contended that information published on the Web amounts to a form of “collective intelligence” that can be used to spot trends and make predictions.

Google Flu Trends appears to be the first public project that uses the powerful database of a search engine to track a disease. This could be the beginning of a new trend in epidemiology. Google hopes to publish the results of its study in Nature.

Until next time…

Good Luck and Good Job Hunting!!!!!!!!

 

Job Hunting in a Recession

I think that it is safe to say that we are in a recession. Even though unemployment is rising to record levels, there are still jobs to be had. To be successful in tough economic times, job seekers must manage expectations and modify job search tactics. To that end, I came across an insightful article that provides jobseekers with a variety of suggestions and tips that may lead to employment during the current economic downturn.

Until next time….

 

Good Luck and Good Job Hunting!!!!!!!!

 

 

Dealing with Corporate Lay Offs and Restructuring on Your Resume

 

Last month, 240,000 American workers lost their jobs. Many of these jobs were lost as a result of corporate lay offs and restructuring—things that are likely to continue as we attempt to navigate a course through these financially troubling times. Unlike being fired, lay offs and job losses that result from restructuring have little to do with individual job performances and everything to do with budget constraints and reductions. That said how should a person who is laid off from a job deal with it on a resume when looking for a new job? I found a well crafted article that provides some ideas and solutions to deal with this often vexing problem.

Read and learn!

Until next time…

Good Luck and Good Job Hunting!!!!!!!!!!

 

The Annual Biomedical Research Conference for Minority Students Rocks!

I just returned from the Annual Biomedical Research Conference for Minority Students (ABRCMS) that was held in Orlando from November 5-8, 2008. The annual meeting, which is configured like most life sciences conferences with plenary oral sessions and poster presentations, is primarily intended to expose minority students to possible career opportunities in the life and biomedical sciences. I was at the meeting working for FASEB Careers as a career development and resume critiquing consultant.  

I have to say that this year's  ABRCMS was one of the most exciting and motivational meetings that I have attended in my career as a scientist and educator. Part of  the excitement and upbeat feeling at the meeting may have been a direct  result of last Tuesday's historic election of Barack Obama (who wasn't excited?).  Nevertheless, I met countless numbers of bright,  highly motivated and talented minority students who want to pursue careers in science, medicine and sometimes both! I was pleasantly surprised to learn that many of the undergraduate students who attend this meeting are actively engaged in basic research in laboratories at their institutions. Further, unlike many of their non-minority counterparts, most of the students who I chatted with were well informed about their intended careers and had divined well thought out strategies to help them realize their career goals and aspirations.

Kudos to the conference organizers and their sponsors! I look forward to attending next year’s conference in Phoenix, AZ.

Until next time…

Good Luck and Good Job Hunting!!!!!

 

 

Optimer's New Carbohydrate-Based Antibiotic May Be a Winner

Optimer, a San-Diego, CA-based biopharmaceutical company, reported positive Phase III clinical trial results for OPT-80, its lead treatment for Clostridium difficile gastroenteritis. C. difficile gastroenteritis is caused by exotoxins secreted by clostridia that have colonized the colon following prolonged antibiotic treatment for other bacterial infections. If left untreated, patients can die from a pseudo-membrane that forms in the colons of C. difficile-infected people. The incidence of C. difficile gastroenteritis has drastically increased over the past decade because of prolonged treatments with multiple antibiotics that are often necessary to eradicate infections caused by multiple drug resistant bacteria.

Historically, CHO-based drugs (with a few notably exceptions like heparin) have not fared well as therapeutic agents. To my knowledge, OPT-80 is the first synthetic carbohydrate (CHO)-based antibiotic to demonstrate anti-bacterial efficacy in a Phase III clinical trial. Having worked for Transcell Technologies (now defunct) and Alchemia,Pty—both of which attempted to develop CHO-based antibiotics—Optimer’s clinical success with OPT-80 is certainly noteworthy. I wish the company continued success in the future—mostly because I have always thought that carbohydrates would make good antibiotics!

 

Until next time…

 

Good Luck and Good Job Hunting!!!!!!

 

 

The Dark Ages for American Science Are Over!

The election of Barack Obama last night signals the beginning of the end of the dark ages that have plagued American science for the past 8 years. I hope that one of the first things that Mr. Obama does after he is sworn in as President is to lift the ban on embryonic stem cell research in this country. This unprecedented ban has done more to harm to American science than most lay people realize. Because of it, we are light years behind other countries which have been able to conducted unfettered research in this area.

The second thing that President Obama must do is to restore the funding levels to the National Institutes of Health and the National Science Foundation so that American scientists will have sufficient funds to innovate once again. For the past 5 years or so, many of my friends in academia were more focused on trying to keep their jobs than concentrating on divining cutting-edge research. 

Finally, and perhaps most importantly, Mr. Obama must overall the United States Food and Drug Administration (FDA) so that the American public can once again believe that prescription drugs that are marketed and sold in the US are safe and efficacious.

On a personal note, the last 8 years have felt like an eternity to me—both a scientist and a citizen. Whether or not Barack Obama lives up to his campaign promises, our next President is a man of intellect, vision and a sense of social justice. That said, this is the first time in many years, that I can truly say that I am proud to be an American!!!

The change is coming…!!!!!!!!!!!!

Until next time…

Good Luck and Good Job Hunting!!!!!!!!!

 

GlaxoSmithKline to Restructure US Pharma Operations

The Pharmalot blog reported yesterday that GlaxoSmithKline (GSK) will tell its US pharma employees today about a new reorganization plan that will include more job cuts. The restructuring will primarily affect sales reps and some R&D personnel. GSK, like most other pharma companies, has been steadily downsizing operations and headcount for the past year or so at its US locations in Research Triangle Park, NC and Philadelphia PA

Look for the layoffs to occur before Thanksgiving—just about the time when employee’s annual bonuses are calculated.

Until next time…

Good Luck and Good Job Hunting!!!!!!!!

P.S.  It was learned today by the Phamalot Blog that 1,880 sales reps and sales support staff job will be eliminated over the next few months. Also, the company may consolidate its Philadelphia and Research Triangle Park headquarters.

 

Pharmaceutical Industry is Losing its Reputation As an Ethical Industry

According to a recent analysis conducted by Covalence a Geneva Switzerland-based organization that tracks the ethical reputation of multinationals, the pharmaceutical industry’s ethical reputation dropped from first to third on Covalence’s all-time EthicalQuote ranking that monitors 10 industries. Further, over the past year, pharma has only managed to achieve an overall ranking of 8th on the list.

The reasons given for the ongoing decline are increased attention on product risk and decreasing media coverage of donations and philanthropy of pharmaceutical companies. The recent high profile coverage of the safety risks associated GlaxoSmithKline’s Paxil and Merck’s Vioxx are good examples of why the ethical image of pharma continues on its downward spiral.

To improve their image, ethicists recommend that drug companies showcase innovative drugs in poor countries, reduce prices to increase access to drugs and loosen intellectual property rights so that there is global access to potentially life-saving drugs. While several companies like Merck and Roche have gone down this path, it may be too little too late.

Until next time…

Good Luck and Good Job Hunting!!!!!!!!

 

At Last: A Website for Salary Comparisons and CEO Reviews

Do you ever wonder what the person who you share an office with is making? Or, have you ever wondered what other people think about the CEO of your company? Or, should I consider working at that company? The answers to these questions and more can now be found at a 4-month old website called Glassdoor.com.

The well designed and easy–to-navigate website allows employees to anonymously post their salaries and write uncensored reviews about their bosses, fellow employees and the companies at which they work. The site also ranks executive performances based on the reviews that it receives.

It is a wealth of information and a must for people who are looking for new jobs or career opportunities. Two of the most important questions that all jobseekers want answered when looking for a new job are compensation and the quality of a workplace environment or corporate culture. Until now, these things were difficult to parse. Not anymore! Check out Glassdoor.com and you might find answers to those nagging questions that you may have about your company, colleagues and CEO!

Until next time…

Good Luck and Good Job Hunting!!!!!!!!!!!!

 

 

Looking to Improve Your Business Acumen?--A New Mini-MBA for Biotech

I am frequently asked by life sciences PhDs whether an MBA would improve their chances of finding a job in industry. And, my response is always “maybe— because it depends. I don’t think that getting a traditional MBA really gives you that much of an edge especially if you are an established PhD looking for career advancement or change.  However, if you are a graduate student or postdoc who has already decided that academia is not for you, then getting a certificate or M.S. through an established graduate program in biotechnology (Georgetown University’s M.S. in biotechnology or The New York Center for Biotechnology's  Fundamentals of Bioscience Program) may increase the likelihood of winning a job in industry. This is because hiring managers recognize that in addition to a job candidate’s technical competency, they possess an understanding of the business aspects of the industry—something that is vital for scientists to be successful in the biotech biz.

Recognizing this, Rutgers University recently created a program that they call ‘a mini-MBA for the biopharmaceutical industry’. In contrast with traditional MBA or M.S. programs, the mini-MBA is a 12 week long, degree-granting program that was designed to familiarize students with the nuances and intricacies of the business aspects of the biopharmaceutical program. The good news is that they are actively recruiting students to fill the slots available in their inaugural class. The bad news is that it costs $4,995 to enroll. That said, it may be worth the time to check it out because—in the end—the investment may be worth it!

Until next time…

Good Luck and Good Job Hunting!!!!!