Are US Immigration Laws Really Hurting Life Science Innovation?

A report in Bloomberg News today suggested that Eli Lilly & Co. Chief Executive Officer John Lechleiter, PhD told a technology conference today that unfavorable US permanent resident (green card) laws are to blame for declining US innovation in the life sciences. With this in mind, Lechleiter plans on calling for US immigration officials to issue more green cards and adopt a shorter and simpler process for highly skilled foreign nationals to gain permanent residence in the US. According to Dr. Lechleiter, one of only a handful of big pharma CEO who is also a PhD-trained scientist, current green card regulations are so-called job killers and force many talented foreign nationals to return to their native countries to work with firms that directly compete with American life sciences companies. Unlike most of his peers, Lechleiter has been very outspoken about the lack of US life sciences innovation.

While Lechleiter comments may have been appropriate five or more years ago, they are no longer germane to America’s waning innovation in the life sciences. There is little doubt that many bright and talented foreign nationals were denied permanent residency during the Bush era (2000 to 2008) because of stringent immigration policies and limits on the numbers of green cards allotted for persons from certain parts of the world; mainly China, India and the Middle East. This, in turn, forced many life scientists—many of whom desperately wanted permanent residency in the US—to return to their home countries to look for work and gainful employment.

As Lechleiter rightly asserts, these scientists found work with companies that began to directly compete with US life sciences. This phenomenon, coupled with the rapid assent of the middle class in many of these nations, made it possible to begin to conduct Western style research at a much lower costs in these countries. To that end, by 2007, most big pharma companies—many of whom had dwindling pipelines and monstrous overhead costs—realized that it would be more cost effective to outsource or move R&D to countries with emerging pharmaceutical and biotechnology markets and a well trained R&D workforce. And, for the past four years downsizing and outsourcing of R&D are exactly what have been taking place at many American big pharma and biotechnology companies.

In my opinion, the larger question that must be addressed, as far as US innovation in the life sciences is concerned is: why are so few Americans willing to pursue scientific careers? To wit, the main reason why so many foreign life scientists were educated and trained in the US over the past 20 years was because there weren’t enough American students to fill the incoming roster at most American graduate training programs. Put simply, America’s growing lack of innovation in the life sciences over the past decade can be directly attributed to far fewer Americans pursuing scientific careers and an increased reliance on foreign nationals—who were unable to stay in the US—to innovate! While changing US immigration laws may allow some foreign nationals to more easily remain in the US, there simply aren’t enough life sciences jobs left in the US to make it worth their while! In fact, the likelihood of them finding life sciences jobs in their home countries is now greater than it is in the US. In my opinion, the only way to restore American innovation in the life sciences is to convince American students that pursuing scientific careers is worthwhile and that the requisite training for industry jobs is available to them.

Interestingly, after leading with changes to US immigration laws, Lechleiter also suggested that America’s innovation problem could be solved by lowering US corporate tax rates and American companies should not be forced to pay taxes on oversea earnings. Also, he asserted that the US Food and Drug Administration (FDA) should stop putting off decisions or erring on the side of avoiding risk when considering new drug applications. 

This begs the questions, how do lower taxes, no overseas taxes and expedited drug approvals help to spur American innovation when most life sciences R&D is conducted outside of the US?

Until next time...

Good Luck and Good Innovating!!!!!!!!

 

Bayer CEO: "Make Me An Offer!"

Bloomberg news today reported that Bayer AG’s Chief Executive Officer Marijn Dekkers said that he would consider a “merger of equals” to bolster the company’s sagging healthcare division. The division, a minor revenue source for Bayer AG, posted $25.1 billion in sales last year.

While Dekkers did not name the companies that he considers to be Bayer’s “equals”, convention wisdom suggests the list is likely to include Eli Lilly & Co, Bristol Myers Squibb (BMS) and Amgen, one of the last remaining, large, independent biotechnology companies. Lilly and BMS both  had  sales revenue similar to Bayer's last year whereas Amgen had lower sales of $15.1 billion. 

The reasons for a potential merger are not entirely clear. However, Bayer Healthcare is waiting to hear about regulatory approval of its new anticoagulant Xarelto medicine for irregular heartbeat patients who face the risk of a stroke. Analysts predict that Xarelto may exceed $2.5 billion in global sales. Approval of Xarelto will change Bayer’s valuation and consequently, don’t expect merger talks to begin until after FDA renders its decision on the drug.

Meanwhile, Bayer’s top-selling multiple sclerosis (MS) treatment betaseron faces competition from a similar Novartis drug called Extavia, and from its new oral MS medication Gilenya. Sales of betaseron fell 5 percent in the first quarter. Moreover, sales of Bayer’s birth-control pill Yaz dropped 18 percent after Teva Pharmaceutical Industries Ltd. introduced a generic version of the medicine.

Lilly, BMS and Amgen all face significant challenges in the future and both BMS and Amgen have been repeatedly mentioned as takeover targets. However, from a historical perspective mergers of mediocre or struggling companies rarely yield stronger, more financially robust ones! But, what do I know, I am just a scientist!

Stayed tuned for more updates.

Until next time...

Good Luck and Good Job Hunting!!!!!!!

 

It Had To Happen Sooner Or Later: FDA Slaps J&J With A Consent Decree For Permanent Injunction

The US Food and Drug Administration yesterday announced that a consent decree of permanent injunction has been filed against McNeil-PPC, the consumer products division of Johnson and Johnson, and two of its senior executives, for “failing to comply with current good manufacturing practice requirements as required by federal law. The action prevents McNeil, a subsidiary of Johnson & Johnson, from manufacturing and distributing drugs from its Fort Washington, Pa., facility until the FDA determines that its operations are compliant with the law.”

McNeil Consumer Healthcare Division’s Vice President of Quality Veronica Cruz and the company’s Vice President of Operations for OTC Products Hakan Erdemir were named defendants in the consent decree, filed with the U.S. District Court for the Eastern District of Pennsylvania in Philadelphia on March 10, 2011. The highest ranking company executives in charge of the facilities named in a consent decree are always included (by law) on the civil action.

The decree also requires McNeil to adhere to a strict timetable to bring its facilities in Las Piedras, Puerto Rico, and Lancaster, Pa., into compliance.

Consent decrees are civil actions—not criminal ones— and are meant to be remedial rather than punitive. In other words, there are no fines levied and the agency expects the companies under consent decree to bring their manufacturing facilities back in to compliance with Current Good Manufacturing Practices (CGMP). However, if the company fails or refuses to comply with the FDA, criminal charges can be filed against the companies and the two executives mentioned in the consent decree. The agency had little choice but to seek a consent decree of permanent injunction against McNeil because of manufacturing problems and recalls of several of its signature brands including Tylenol, Motrin, Zyrtec, and Benedryl. Criminal charges may be forthcoming because of possible cover ups of the recall that involved hiring outside contractors to purchase tainted produced in bulk to surreptitiously remove them from store shelves.

FDA had little choice but to seek a consent decree because of the seriousness and continuous nature of the problems at its Fort Washington production facility and the fact that J&J senior executives were either unaware or unconcerned with the problems at its subsidiaries. While working under a consent decree may be embarrassing for J&J, the damage caused by the recalls of some of its most visible consumer and OTC brands may be irreparable.

 Until next time...

Good Luck and Good Job Hunting!!!!!!!!!!

 

Decline in High School Student Participation at Science Fairs: The Obama Administration Responds!

The recent article published in the NY Times about the decline of high school student participation in science fairs resulted in many letters to the editor. Many of them were from concerned citizens and a few were from university researchers decrying the lack of government funding for research and the funding of sports over science programs. Another railed against the Bush’s Administration’s poorly crafted and ill-advised No Child Left Behind Act. However, there was one letter that surprised me. It was written by John P. Holdren, President Obama’s science and technology adviser (see below)

To the Editor:

Your article points to deep budget challenges that many school districts are facing and problems with the Bush administration’s No Child Left Behind law.

But it does not mention much of the Obama administration’s extraordinary agenda for improving science, technology, engineering and mathematics (STEM) education in this country: for example, the commitment to prepare 100,000 new math and science teachers over the next 10 years, the $4 billion Race to the Top program’s support for innovation in teaching these important subjects, and the administration’s blueprint for updating the Elementary and Secondary Education Act this year.

Recognizing that government alone cannot be the answer, moreover, the president has also called upon the business community, foundations, professional societies and others to do more. Already, the president’s “Educate to Innovate” campaign has attracted more than $700 million in nongovernmental financial and in-kind support for science and math programs.

And more than 100 chief executives have responded to the president’s “all hands on deck” call to action by launching “Change the Equation,” an unprecedented program to scale up effective models for improving STEM education.

John P. Holdren
Washington, Feb. 7, 2011

The writer is President Obama’s science and technology adviser.

What surprised me about the letter is that it took an article critical of the Obama Administration’s commitment to science education to provide the American public (at least part of it) with some insight into the government’s recognition of the problem and steps that it is taking to help to correct it. Perhaps the Obama administration needs to be a bit more proactive and publicly-vocal about its plans to improve American STEM education. This would go a long way to assuage some of the concerns about America's waning global competitiveness in science and technology.

Like Dr. Holdren, I believe that government alone cannot be the answer and American corporations must get actively involved by providing ideas on how to improve American science education and the financial support to implement them. While the CEO-endorsed program “Change the Equation” sounds great on paper, it is time for those CEOs to actually step up and do something about the problem. Many of these same CEOs have been complaining for decades about the lack of STEM preparedness of the American workforce. As somebody once said “Talk is cheap and actions speak louder than words!”

Until next time...

Good Luck and Good Teaching!!!!

 

Sanofi Inching Closer to Purchasing Genzyme

The buzz at the JP Morgan Healthcare Conference that is taking place in San Francisco this week is that Sanofi-Aventis and Genzyme are close to inking a deal. As you may recall, Sanofi made an unsolicited offer last summer to buy the troubled orphan drug manufacturer. Sanofi offered to purchase Genzyme for $69 per share but the offer was summarily rejected as “too low” by Henri Termeer, Genzyme’s embattled CEO who has been running the company for over 20 years since its inception.

The very public and often acrimonious haggling over the purchase price has become legion in some investment banking and bioventure circles. Nevertheless, most industry and financial analysts predict that Sanofi will prevail and ultimately acquire Genzyme possibly for a share price in the low to mid $70s.  Sanofi desperately needs Genzyme to get into the biotechnology fracas; a field that it seemingly chose to largely ignore for the past 20 years--go figure!  Consequently, it is likely that Sanofi will eventually give Genzyme everything it wants to consummate the deal

Yet, despite progress being reported from the conference, Termeer and Sanofi Aventis CEO Chris Viehbacher haven’t met face-to-face to discuss the terms of a possible deal. However, Viehbacher did mention that Sanofi was “still committed” to purchasing Genzyme.

Stay tuned for the next installment of the saga.

Until next time...

Good Luck and Good Job Hunting!!!!!!!!

 

Tis the Season....Pfizer's CEO Abruptly Announces His Departure

Late last week, Merck appointed Ken Frazier, a lawyer, to be the company’s next CEO. Frazier’s appointment, while expected, was historical because he was the first African American tapped to be the CEO of a major pharmaceutical company. Industry insiders contend that Frazier’s unlikely ascension is a tribute to his affability, PR prowess and ability to successfully use his considerable legal skills to navigate Merck through its troubled Vioxx era. 

On the other hand, industry analysts and Pfizer shareholders have been less enamored of the performance of Jeffrey B. Kindler, another lawyer, who has led the company since 2006 when its former CEO Hank McKinnell Jr tried to single-handedly destroy the world’s largest drug maker. Kindler joined Pfizer in 2002 as its chief counsel after working at General Electric and McDonalds—clearly a man with little or no previous pharmaceutical industry experience. While critics contend that Kindler did a laudable job after stepping into the breech, there was consensus among a majority of Pfizer shareholders that it was time for a change at the top.

In a statement Sunday, Kindler announced that he wanted to “recharge my batteries, spend some rare time with my family and prepare for the next challenge in my career.” During his tenure, Kindler oversaw the acquisition and merger of Pfizer and Wyeth and successfully oversaw a settlement for illegal marketing of the painkiller Bextra which included a $1.3 billion criminal fine: the largest health care fraud case and criminal fine for a pharmaceutical company in US history.

The reason for Kindler’s unexpected and sudden departure is likely the impending patent expiry (2011) for its top selling cholesterol drug Lipitor (Pfizer acquired Lipitor after purchasing Warner Lambert Pharmaceuticals in the mid 1990s). Recent financial reports indicate that Lipitor accounted for $11.4 billion of Pfizer’s $50 billion in sales last year or 23% of its revenue. Most industry analysts agree that navigating Pfizer in a world without Lipitor will require an individual with many years of pharmaceutical industry experience and moxy.

To that end, Pfizer announced that Ian Read, currently head of the company’s biopharmaceutical operations will immediately take over as CEO. According to a profile on Forbes.com, Read is:

Senior Vice President; Group President, Pfizer Biopharmaceutical Businesses since October 2009. Previously, he was President Worldwide Pharmaceutical Operations from August 2006 until October 2009. Mr. Read has held various positions of increasing responsibility in pharmaceutical operations. He previously served as Area President for the Europe, Canada, Africa and Middle East and Latin America regions and Senior Vice President of the Pfizer Pharmaceuticals Group. Mr. Read was elected a Vice President of Pfizer Inc. in April 2001.

Also, Pfizer’s board of directors said that it would elect a new chairman (another position vacated by Kindler’s departure) at a meeting within the next two weeks.

Until next time...

Good Luck and Good Job Hunting!!!!

 

Merck Taps Ken Frazier as Its New CEO--The First African American to Lead a Major Pharmaceutical Company

Merck has finally gone where no pharmaceutical company has ever gone before; it today named Ken Frazier, a Harvard-trained African American lawyer as its next CEO. Frazier, who joined Merck in 1992, became general counsel in 1992 and was promoted to President of Global Human  Health last April will succeed Dick Clark (the other one) who will soon reach Merck’s mandatory retirement age of 65. Frazier has always been something of a rising star and his stock (pun intended) has rapidly risen in recent years mainly because of the prominent role he played in managing the fallout from the Vioxx scandal.

While today’s announcement may have been history making, Frazier’s ascension to the top position at Merck was widely expected. Frazier has played a key role in the integration of Schering Plough, which Merck purchased almost two years ago for $42 billion.

Like Clark, Frazier is not a scientist. Given Merck’s thinning pipeline and recent setbacks with its anti-cervical cancer vaccine Gardasil, Frazier, like Clark will have his work cut out for him to restore Merck’s tarnished image to its once impeccable standing in the pharmaceutical industry.

Until next time...

Good Luck and Good Job Hunting!!!!!!

 

Despite Assertions to the Contrary Novartis Lays Off 1,400 Sales Reps

Despite public assertions made by Novartis a mere eight days ago that it would not be eliminating thousands of jobs, the company today announced that it was eliminating 1,400 sales reps. Roughly 1,150 jobs will be cut from its primary care division—which is being consolidated into three units from four in the US—and another 250 from psychiatric and neuroscience. No jobs will be eliminated from Novartis’ headquarters in Hanover, NJ. While the job cuts announced today were not in the thousands (almost) it isn’t clear whether or not more are to come.

According to a post on today’s Pharmalot blog:

"Novartis had attempted to dampen speculation that a huge bloodletting was imminent after Roche disclosed plans to axe 4,800 jobs worldwide (back story) and, in fact, Joe Jiminez, the CEO, had written on his internal blog that news reports about big layoffs were inaccurate. Technically, the Novartis reduction is not in the thousands, but the number is still large and, essentially, confirms concerns that have been expressed over the past month at CafePharma, the online forum where reps dish the dirt (look here)."

Don’t you just love the holidays?

Until next time...

Good Luck and Good Job Hunting!!!!!!!!

 

Ho-Hum: Another Day, Another Pharmaceutical Company Joins the Social Media Fracas

The ever watchful Mark Senak of the highly informative EyeonFDA blog today reported that Eli Lilly had taken the social media plunge by creating a twitter account (@Lillypad) and also launching a blog cleverly entitled the LillyPad (get it; pad=launching point etc and the word pad is hot because of the iPAD). Ah, those clever pharmaceutical marketers; they never miss a thing!

As Mark points out in his post, Lilly had previously launched a YouTube Channel in 2008 called LillyDiabetes that almost immediately disappeared after he first blogged about it! According to the EyeonFDA post Lilly launched the blog and joined Twitter

"[b]ecause we feel passionately about a lot of issues that are important to our company and our industry, and we know there's plenty of passion well beyond our own walls.  Policy issues like health care reform have been top-of-mind with the public for a long time.  And industry watchers are placing an increased premium on trends like corporate citizenship.  These are important dialogues, and we're happy to provide a forum and participate."

However, as Mark aptly posited in his post, why are we so amazed when a pharmaceutical company launches a blog or engages in a social media campaign? After all, recent research indicates that nearly one-third of companies are blogging and that number is expected to increase to 43 percent by 2012. In fact, pharmaceutical company blogs are quickly becoming de rigueur. So, don’t be surprised if other companies jump on the social media bandwagon over the coming months. Maybe in the future the launch of a pharmaceutical blog, Facebook page or Twitterfeed may no longer be big news or even worthy of a blog post!

A quick perusal of the LillyPad blog reveals that many of the posts deal with issues like improving math and science education, job creation, American innovation, and healthcare solutions. Interestingly, many of these posts are consistent with recent public statements made by Lilly’s CEO John Lechleiter, PhD. It would be great if the LillyPad blog continues to post articles that provide Lilly stakeholders with insights into what management is thinking. This will certainly go a long way to help to create a “conversation’ between the blog and its followers: something that is critical to the success of any corporate social media campaign.

Until next time...

Good Luck and Good Job Hunting!!!

 

Words of Wisdom from the Executive Suite

For the past few years, CEOs have been taking a lot of heat; and in many cases rightfully so. However, from time to time some of these “captains of industry” say things that may be useful to ambitious young executives, employees and would-be entrepreneurs. 

The folks over at BestCollegesOnline sent me a link to a post entitled “The 30 Best CEO Interviews You Should Watch on YouTube.” While I haven’t seen any of the videos (I don’t have the luxury of time to do so), viewing some of them may be worth it!

Check them out and let me know if find a good one.

Until next time...

Good Luck and Good Job Hunting!!!!!!!!!

 

More Interviewing and Hiring Tips From the Executive Suite

In this week’s New York Times “Corner Office”, Aaron Levie, the 25 year old CEO of Box.net a Silicon Valley online file storage company had provided these valuable insights and tips about interviewing and hiring new employees. 

Q. Let’s talk about hiring.

A. One thing that’s really important is understanding what they’ve done in their career. Just walk me through how you got to where you are today. What are the factors that led to specific decisions — that can give you a level of insight into behavior and how they make decisions.

Energy and persistence are the two most important factors, in addition to just having a clean résumé where there’s nothing crazy going on.

Curiosity is another big thing and a way to identify who’s going to be energetic and have the right attitude.

Q. If you could ask a job candidate just a few questions, what would they be?

A. “What questions do you have for me?” That will help you see how they’re thinking about the challenges. A lot of times I’ll say, “When you’re thinking about Box as an opportunity, how do you compare it to other organizations? What do we have that you want to be a part of?” Getting them to articulate the values back to you about what kind of organization they want to be a part of can actually be very useful.

Although Mr Levie is only 25 years old, the things that he looks for in new hires and the type of questions that he asks during face-to-face (F2F) job interviews have stood the test of time!

For the complete interview, please visit.

Until next time

Good Luck and Good Job Hunting!!!!!!

 

Lilly CEO: "US is Losing it Edge in Life Sciences Innovation"

John Lechleiter, PhD, chairman and CEO of Eli Lilly & Co. today told members of the Detroit Economic Club that the US is losing its competitive edge and that “evidence is mounting for an innovation crisis in the life sciences

Lechleiter blamed the crisis on US tax and immigration policies over the last 10 years that have reduced research and investment funding and driven away foreign-born, U.S.-trained scientists.

He also attributed the problem to the US Food and Drug Administration’s new emphasis on drug safety.  “The FDA approved 92 drugs the last five years. That is the lowest of any five-year period,” he said. “We lose patent protections (on brand name drugs) and that is $100 billion less revenue for the industry and less for research and development” said Lechleiter. Further, he said that “American drug companies still spend 40 percent more on research in development in the U.S. than in other parts of the world.”

To avert the crisis, Lechleiter suggested the following: 

  1. Increase and improve education for students in math and science
  2. Change immigration laws to allow more H1-B visas for scientists and ease the process that allows immigrants to gain green cards to work in the U.S. The last time the H1-B visa cap was raised was in 1990
  3. Increase federal funding for pharmaceutical and basic science research, which has declined over the last five years
  4. Change tax policies to provide more incentives for research and development. The U.S. lags behind the rest of the world in offering R&D tax credits, he said. Moreover, the U.S. should not tax foreign subsidiaries of U.S. corporations

Lechleiter, who was trained as a chemist, is the only CEO of a major pharmaceutical company who holds a PhD degree. Therefore, his ideas resonate more for me than those of his business-only CEO counterparts. To that end, his suggestions regarding improving math and science education, immigration reform (which I have long contended is killing US competitiveness) and increasing federal funding for research make sense. However, the notion that US tax laws and lack of corporate tax incentives is stifling American innovation and competitiveness is pure hogwash.

While corporate tax rates may be higher in the US than elsewhere, there are so many loop holes that most corporations pay less than their share fair. Further, let’s not forget that the personal income tax rate is much higher in the rest of the developed world than it is in the US. It is just so “American” to not want to pay taxes and then demand and expect government services at no cost to the taxpayer (at least in Europe they pay high taxes and get good services).  And, let's not forget that despite their heavy tax burden it was American corporations not foreign ones that caused the recent global recession.

That said, I gotta give John some credit for his suggestions; three out of four (or a .750 average) isn’t bad in baseball or the pharmaceutical industry!

Hat tip to Ed at Pharmalot

Until next time...

Good Luck and Good Job Hunting!!!!!!

 

AstraZeneca to Freeze Salaries of Its CEO and Other Executives

AstraZeneca today announced that its Chief Executive David Brennan will receive no increase to his base salary this year, as the drug maker continues a freeze for top executives imposed last year due to weak economic conditions.

Brennan's 2010 salary will remain at $1.4 million, the same level since 2008. However, Brennan’s overall compensation has been on the rise for the past few years. His total remuneration, which includes bonus, shares and other items, rose 5% to $4.9 million for 2009, versus $4.7 million for 2008, according to documents recently filed with the Securities and Exchange Commission.

AstraZeneca said the base-salary freeze for 2010 also applies to other senior executives whose responsibilities are unchanged. 

While it is laudable that the company is freezing the base salary of its executives, most of their annual compensation is derived from bonuses, stock grants and options and other perks and benefits. I am certain that the hundreds of thousands of pharmaceutical employees who lost their jobs over the past three years can sleep better at night knowing that pharmaceutical executives are finally feeling the pain and sharing the pain of a down economy.

Hat tip to Ed at Pharmalot!

Until next time…

Good Luck and Good Job Hunting!!!!!!!!!!

 

Johnson & Johnson Freezes Salaries and Cuts Yearly Bonuses

Times are tough in the financially-struggling pharmaceutical industry and seemingly getting tougher.

First, Bristol-Myer Squibb (BMS) announced last week that it will freeze salaries but not cut yearly performance bonuses for its employees. One week later, Johnson & Johnson (J&J)—a company known not to be upstaged or outdone by a competitor—is planning on cutting the yearly performance-bonuses for 38% of its workforce and will freeze the salaries of certain other employees.

While BMS publicly announced its salary freeze, J&J plans were uncovered in an internal announcement and other company documents obtained by The Wall Street Journal. According to the Journal article, “The health-care giant told employees Jan. 25 that it is making the moves to standardize compensation across its various businesses and regions, thereby making it easier for its workers to move around within the company. In the U.S., the changes will bring bonus targets in line with market levels, one document said.”

Interestingly, J&J hasn't yet reported its CEO, William Weldon’s compensation for last year. In 2009, Mr. Weldon turned down a salary raise. His total compensation in 2008 fell 4.1% from the year before to $29.4 million, according to the most recent regulatory filing.

The salary freeze and bonus cuts help to explain why a good friend and lifelong J&J employee (25 years and counting) wasn’t too keen on the company during a visit earlier this week. During a conversation, in which I unknowingly lauded J&J’s treatment of its employees, my friend quipped “Looks can be deceiving; J&J is like every other big corporation. People really don’t matter—it’s all about P&L”

Until next time...

Good Luck and Good Job Hunting!!!!

Fred Hassan Shares His Views on the Past, Present and Future of the Pharmaceutical Industry

I just received a phone call from UK-based Meettheboss.TV to give me advance notice of an interview that was conducted with Fred Hassan, the former CEO of Schering Plough, that will be shown tomorrow at the Meettheboss.TV website. Hassan stepped aside as CEO after Merck acquired Schering Plough for $41.1 billion late last year.

Mr Hassan is arguably one of the most respected and highly visible pharmaceutical executives in the industry. He sat down with Meettheboss.TV to share how he was able to turn around a dysfunctional and failing Schering Plough and restore its tarnished image.

“I joined a company in 1997 that was in great difficulty.  There has been a merger between a Swedish company and a U.S. company, and that merger had resulted in a lot of difficulties, I was brought in as a CEO from the outside to try to make this merger work.  I realized that the future growth product of this company has been compromised in a deal that had to be untangled.” Fred told Meettheboss.tv

In an uncharacteristically candid interview, Hassan also offers his personal insights and views on the challenges that the pharmaceutical industry faces in the future as traditional business models begin to change and new players enter the pharmaceutical industry space. 

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To watch the full interview, please visit Meettheboss.TV

Until next time....

Good Luck and Good Viewing!!!!!!!!

Shuffling of Executives at Novartis: Vasella is Out as CEO

The Pharmalot blog authored by the intrepid Ed Silverman today reported that Dan Vasella is out as CEO at Novartis and there has been an executive shake up at the company. According to the post, Vasella is reliquishing his post a CEO but retaining his chairman title For a complete run down and a glimpse at the new Novartis org chart read Ed's post

Vasella has come under fire (literally and figuratively) over the past year or so.  Industry insiders and Novartis shareholders contended that he couldn't manage the day-to-day operations of companies and succeed as Chairman. Also, Vasella was the victim of  unwarranted, vicious attacks by animal rights activists who publicly denounced him and set his home on fire!

Vasella, one of the few physicians to head a pharmaceutical company, held the top position since 1996 following the merger of Sandoz and Ciba-Geigy to form Novartis. The company has expanded in to new therapeutic areas and markets and performed well under Vasella's stewardship. However, many industry experts contend that ten years is the optimum tenure for most life sciences CEOs. What's four years in the scheme of things?

Until next time....

 Good Luck and Good Job Hunting!!!!!!!

Roche Shakes Up Leadership At Genentech

Roche announced Tuesday that it will replace Arthur Levinson, PhD, Genentech’s current CEO and American biotechnology pioneer, with Pacal Soriot, DVM, MBA who currently leads Roche’s worldwide commercial operations.  Dr. Levinson will become Chairman of Genentech’s newly configured board of directors but no longer have control over day-to-day operations at the company.  Mr. Soriot will become CEO of Genentech and head all of Roche’s pharmaceutical activities in the US. Some of the other changes that will occur at the company include: Susan Desmond-Hellmann, Genentech’s president of product development, will move into an advisory role after the middle of this year. Genentech CFO David Ebersman is leaving the company and Ian Clark, who heads commercial operations for Genentech, will be chief marketing officer of Roche’s pharma division.

Dr. Levinson and Mr. Soriot will lead the efforts to combine all of Roche’s North American operations which ultimately will be run from Genentech’s South San Francisco location. Many of the activities at Roche’s previous North American headquarters in Nutley, NJ will move west, which means downsizing, more layoffs and possible closure of the Nutley site. 

Dr. Levinson, one of Genentech’s early employees, joined the company as a senior scientist in 1980 and has been its chief executive since 1995. During his tenure, Genentech became the largest, most profitable and perhaps the most innovative biotechnology company in the US. Unlike Dr. Levinson, who is a molecular biologist and has over 30 years of experience in developing successful protein-based drugs, Dr. Soriot, a former Sanofi-Aventis financial and commercial operations executive has little or no experience with biotechnology products.

With this in mind, I suspect that many things will change at Genentech as Roche attempts to transform the once heralded biotechnology company into a subsidiary of its pharmaceutical division. Don’t be surprised if you see a mass exodus from company. Farewell DNA, all good things must end!

Until next time...


Good Luck and Good Job Hunting (try Genentech, there will be openings soon)
 

Immediate Fallout from the Pfizer-Wyeth Deal

The ink hasn’t had time to try on the deal sheet and Pfizer already has announced what the impact of its acquisition of Wyeth will have on the combined company. Here’s what to expect: Pfizer will shed at least 19,000 jobs from it newly combined work force of 128,000 employees; it will slash its stock dividend by 50%; and it will take a $2.3 billion charge to settle a federal investigation over off label promotion of its former pain drug Bextra. 

The combined company will be run by Pfizer’s CEO, Jeff Kindler, who joined Pfizer in 2006 after serving as legal counsel for McDonald’s. Bernard Poussot who became Wyeth’s CEO a little over a year ago will depart the company. As I mentioned in a post yesterday, Pfizer and Wyeth had been in talks for over a year before the deal was consummated. If the deal had closed last year, Mr. Poussot would have garnered a $38 million dollar severance package that included cash, pension, health benefits and other entitlements. But, because Wyeth’s board changed its compensation package for its CEO on January 1, he will only be entitled to a severance package of only $18.3 million. Not bad for a guy who ran the company for little over a year!

Other fallout from the deal includes: increased consolidation or purchase of cash-poor biotechnology companies—that will result in more layoffs and continue to reduce the life sciences workforce in the US— and the loss of a potential biotech dealmaker (Wyeth) that was aggressively pursuing M&A strategies and licensing opportunities with smaller, struggling biopharmaceutical companies. Most Wall Street analysts agree that the debt taken on by Pfizer to purchase Wyeth will prevent the company from participating in any new major acquisitions in the foreseeable future.

While the deal may ultimately benefit Pfizer, it certainly won’t help to improve the overall, short term health of the pharmaceutical and biotechnology industries.

Until next time…

Good Luck and Good Job Hunting (I hear that they are hiring on the West Coast)

 

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Congrats to Arthur Levinson, CEO of Genentech

Glassdoor.com a site that allows people to rate CEO and company performance selected Arthur Levinson, one of the original founders and current CEO of Genentech as the “nicest CEO” of the year. Dr. Levinson received a 93 percent approval rating and he is the only biotech CEO on the list. A strategic planner at Genentech wrote “He leads the Silicon Valley biotech company with a “decision-making structure that intrinsically forces authority downward to the lowest possible level providing many opportunities to exercise and test one’s judgment.”  I have worked with Genentech on education and training initiatives in the past and as far as I am concerned it is “second to none” in the biotech industry. 

It is evident from Genentech’s continued success, that Dr. Levinson is truly one of the unsung heroes (and pioneers) of the biotechnology industry. I am glad that he is finally getting the recognition that he deserves.

Until next time…

Good Luck and Good Job Hunting (try Genentech, they are hiring!)

 

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At Last: A Website for Salary Comparisons and CEO Reviews

Do you ever wonder what the person who you share an office with is making? Or, have you ever wondered what other people think about the CEO of your company? Or, should I consider working at that company? The answers to these questions and more can now be found at a 4-month old website called Glassdoor.com.

The well designed and easy–to-navigate website allows employees to anonymously post their salaries and write uncensored reviews about their bosses, fellow employees and the companies at which they work. The site also ranks executive performances based on the reviews that it receives.

It is a wealth of information and a must for people who are looking for new jobs or career opportunities. Two of the most important questions that all jobseekers want answered when looking for a new job are compensation and the quality of a workplace environment or corporate culture. Until now, these things were difficult to parse. Not anymore! Check out Glassdoor.com and you might find answers to those nagging questions that you may have about your company, colleagues and CEO!

Until next time…

Good Luck and Good Job Hunting!!!!!!!!!!!!

 

 

Merck's Best Days May Be Behind It....Again

Oh, what a difference a couple of years or results from a pivotal clinical trial can have on a company’s financial outlook. As you may recall in 2005, Merck was in a shambles after the Vioxx scandal broke. Its CEO was ousted, its stock was trading at less than $35 per share and employee morale was at an all time low. After two short years, Richard Clark, a life-long Merck employee, was able to turn the company around. Merck’s stock reached a high of almost $61 last December and many of its employees were dancing in the streets of Rahway because their stock options were now worth more than the paper that they were printed on. But, like many things in life, all good things must come to an end.

Since December Merck’s stock price has plummeted to $40 and appears to be headed downward. What sparked the retreat was the release of results from the now infamous ENHANCE clinical trial which showed that Vytorin, which is co-marketed by Merck and Schering Plough, offered no greater benefit than a cheaper, generic version of Zocor (one of the two active ingredients of Vytorin) to reduce the risk of heart attack and stroke. The fallout from this revelation has been intense and dramatic. Both Merck and Schering Plough are being investigated by Congress for marketing violations and the financial maneuvers’ of several senior executives from both companies are under intense scrutiny. 

Many industry analysts believe that Merck may be on the ropes again and are afraid that the company may slip back into the morass it found itself in after the Vioxx debacle.

I have always held Merck in high regard–no fewer than 15 people who I went to graduate school have worked at Merck at one time or another. Further, the Merck name used to be synonymous with “second to none” science and outstanding pharmaceutical products. Sadly, over the past decade Merck’s leadership has consistently placed profits before good science causing the American public to lose confidence in one of its flagship pharmaceutical companies. Maybe Dick Clark, who was around during Merck’s glory days, can restore Merck’s reputation by insisting that from now on, good science will always come before corporate profits. Time will tell….

Until next time….

Good Luck and Good Job Hunting!!!!!!!

What to Look For in a "Bad" CEO

According to Terry Leap, a Professor of Management at Clemson University, CEOs that exhibit some or all of the following traits or behaviors are likely to be problems.

  • An obsession with acquiring prestige, power and wealth
  • A reputation for unwarranted and shameless self promotion
  • A tendency to propose “grandiose strategies” and failing to include a detailed plan to carry them out.
  • A superb ability to compartmentalize and rationalize things.
  • A history of emphasizing activity, like hours worked or meetings attended, over accomplishment.
  • A reputation for implementing major strategic changes unilaterally or for forcing programs down the throats of reluctant managers.
  • An impulsive, flippant decision–making style.
  • A love of monologues coupled with poor listening skills.
  • A tendency to display contempt for the ideas of others.
  • A penchant for inconsiderate acts

The thing that worries me is that many academicians and most CEOs that I know exhibit five or more of these traits. Oy! 

Until next time…

Good Luck and Good Job Hunting

Can Scientists Be Effective CEOs?

Over the past 30 years or so, the vast majority of chief executives in the drug business have made their way to the top via the sales and marketing departments. Few senior executives have toiled in a research laboratory or for that matter, know the difference between NMR and protein purification. However, things may be changing in the industry. A quick perusal of the CEOs of the top 20 pharmaceutical and biotechnology companies (see below) reveals that 11 of 20 have degrees in engineering (4), medicine (2) and science (5). The remaining 9 have degrees in business and finance (3), sales and marketing (4) or law (2). Several of the scientists (2), engineers (3) and one physician also earned MBA degrees.

 

Conventional wisdom suggests that scientists usually do not make good CEOs (they are not formally trained in business). However, doesn’t the lack of scientific sensibility put non-scientist CEOs at a disadvantage when it comes to making strategic and operational decisions about R &D?  One would think so….!!!!

 

A careful examination of my top 20 list suggests that some of the most successful companies are run by scientist CEOs, e.g. Genentech, Gilead, Novartis and Lilly. Expect to see more scientist CEOs at large biotechnology and pharmaceutical companies in the future–R&D have become way too complex for non-scientist to truly understand its nuances and potential pitfalls. Plus, we scientists know that obtaining a MBA degree is a “piece of cake” as compared with the PhD degree! Hmmm, I wonder what business people think about PhDs?

Company

Name

Background

2006 Total Compensation

Abbott

Miles White

Mechanical Engineering and Business (MBA)

$26,915,358 

Amgen

Kevin Sharer

Aeronautical Engineering and Business (MBA)

$34,390,000

AstraZeneca

David Brennan

Sales and Marketing

$4,226,000 

Biogen/IDEC

James Mullen

Chemical Engineering

$1,450,000

Bristol-Myers Squibb

Jim Cornelius

Business (MBA) and Finance

$1,472,879

Eli Lilly

John Lechleiter

Chemistry (PhD)

Not available (newly appointed)

Genentech

Arthur D. Levinson

Molecular Biology (PhD)

$17,124,025 

Genzyme

Henri A. Termeer

Finance and Business (MBA)

$36,380,000

Gilead

John C. Martinis

Organic Chemistry (PhD), Chemical Engineering and Business (MBA)

$22,860,000

GlaxoSmithKline

JP Garnier

Pharmacology (PhD) and Business (MBA)

$5,413,000 

Johnson & Johnson

William C. Weldon

Sales and Marketing

$28,557,749 

MedImmune

David Mott

Banking and Investment

$11,411,897

Merck

Richard T. Clark

Business and Marketing (MBA)

$10,236,740

Millennium

Deborah Dunsire

Physician (MD)

$3,874,464

Novartis

Daniel Vasella

Physician (MD) and Business (MBA)

3,199,505 CHF

Pfizer

Jeffery Kindler

Lawyer

$9,799,233 

Roche

Severin Schwan

Lawyer and Finance

Not available (newly appointed)

Sanofi Aventis

Gerard Le Fur,

Pharmaceutical Sciences (PhD)

Not available (newly appointed)

Schering Plough

Fred Hassan

Chemical Engineering and Business (MBA)

$5,790,000

Wyeth

Bernard Poussot

Business and Finance

Not available (newly appointed)

Until next time….

Good Luck and Good Job Hunting!!!!!!!!