Big Changes In Store For Amgen Employees?

Remember when Amgen was the world’s largest and most profitable biotechnology company? That was way back in 2006 before its marketing and sales team got in trouble for “pushing” the sale of its erythropoietin (EPO) product Epogen and Aranesp beyond acceptable patient safety limits. This, along with a relatively thin new drug pipeline, has for the past five years or so relegated the company to second tier biotech company status.

To make matter worse, a company spokesperson mentioned its third-quarter earnings conference call today that the company is

 “...currently evaluating some changes within our Research & Development organization to improve focus and to reallocate resources to key pipeline assets and activities." This typically means that the possibility of layoffs is real. The last major restructuring of the company took place in 2007 and it resulted in the elimination of more than 2,000 jobs worldwide, including about 700 in Thousand Oaks.

This past June, Amgen announced plans to eliminate 134 jobs at two of its manufacturing sites in Colorado.

The company employs about 17,000 people, including about 6,200 in Thousand Oaks. Amgen also has research and development facilities in Thousand Oaks, South San Francisco,; Cambridge and Woburn, Mass.; Seattle; Burnaby, British Columbia, Canada; Abingdon, Cambridge and Uxbridge, Great Britain; and Regensburg, Germany.

In 2010, Amgen's revenue totaled $15.1 billion, while research and development cost $2.9 billion, according to the company. Its net profit last year totaled $4.63 billion, up slightly less than 1 percent from 2009.

Could this signal the beginning of the end of this once formidable biotechnology giant? If I was an Amgen employee I would be feverishly updating my CV right about now!

Until next time...

Good Luck and Good Job Hunting!!

 

US Graduate School Enrollment Dips for the First Time Since 2003

Conventional wisdom has it that when economic times are tough enrollment in graduate schools tends to increase. After all, there are no jobs to be had so jobseekers go back to skill to increase their knowledge or improve their skills to be more competitive on the job market. However, according to a new report issues by the Council of Graduate Schools, enrollment of American students in US graduate programs dropped 1.2% percent from 2009to 2010 despite a 8.4% increase in applications.  This is the first drop in graduate school enrollment since 2003 and the decrease came after a 5.5% increase the previous year. 

The decrease in new graduate students was most noticeable in business (MBA) and public administration programs. Interestingly, enrollment by Hispanic student grew by roughly 5.0% while black enrollment declined by more than 8.0%. A startlingly finding of the report is that the number of new international graduate students studying in the US increased 4.7% percent since 2009 to 2010; a trend that has been taking place mainly in the sciences and engineering for the past two decades which has now crossed over into non-science fields. Finally, another troubling statistic is that while enrollment in certificate and Masters Degree programs is beginning to wane, doctoral programs are growing at a faster rate than ever before.

The reasons for the decline in domestic enrollment are tied to the poor economy. Graduate school costs are rising and employers are no longer willing to pay for graduate education of their employees. Dr. Debra W. Stewart, president of the Council of Graduate Schools issued this warning:

“The decline in domestic students is very bad news for the nation’s economic future. “Higher education and, increasingly, graduate education are what drives prosperity, and if we get to the point where only people with significant bank accounts can afford graduate education, the country is doomed.”

Some other interesting tidbits found in the report included the statistic that more than 60 percent of the 445,000 first-time graduate students were enrolled at public institutions, and about 58 percent of them were women and women earned about two-thirds of the graduate certificates awarded in 2009-10; 60 percent of the master’s degrees; and 52 percent of the doctorates.

Until next time...

Good Luck and Good Job Hunting!!!!!!!!

 

Are US Immigration Laws Really Hurting Life Science Innovation?

A report in Bloomberg News today suggested that Eli Lilly & Co. Chief Executive Officer John Lechleiter, PhD told a technology conference today that unfavorable US permanent resident (green card) laws are to blame for declining US innovation in the life sciences. With this in mind, Lechleiter plans on calling for US immigration officials to issue more green cards and adopt a shorter and simpler process for highly skilled foreign nationals to gain permanent residence in the US. According to Dr. Lechleiter, one of only a handful of big pharma CEO who is also a PhD-trained scientist, current green card regulations are so-called job killers and force many talented foreign nationals to return to their native countries to work with firms that directly compete with American life sciences companies. Unlike most of his peers, Lechleiter has been very outspoken about the lack of US life sciences innovation.

While Lechleiter comments may have been appropriate five or more years ago, they are no longer germane to America’s waning innovation in the life sciences. There is little doubt that many bright and talented foreign nationals were denied permanent residency during the Bush era (2000 to 2008) because of stringent immigration policies and limits on the numbers of green cards allotted for persons from certain parts of the world; mainly China, India and the Middle East. This, in turn, forced many life scientists—many of whom desperately wanted permanent residency in the US—to return to their home countries to look for work and gainful employment.

As Lechleiter rightly asserts, these scientists found work with companies that began to directly compete with US life sciences. This phenomenon, coupled with the rapid assent of the middle class in many of these nations, made it possible to begin to conduct Western style research at a much lower costs in these countries. To that end, by 2007, most big pharma companies—many of whom had dwindling pipelines and monstrous overhead costs—realized that it would be more cost effective to outsource or move R&D to countries with emerging pharmaceutical and biotechnology markets and a well trained R&D workforce. And, for the past four years downsizing and outsourcing of R&D are exactly what have been taking place at many American big pharma and biotechnology companies.

In my opinion, the larger question that must be addressed, as far as US innovation in the life sciences is concerned is: why are so few Americans willing to pursue scientific careers? To wit, the main reason why so many foreign life scientists were educated and trained in the US over the past 20 years was because there weren’t enough American students to fill the incoming roster at most American graduate training programs. Put simply, America’s growing lack of innovation in the life sciences over the past decade can be directly attributed to far fewer Americans pursuing scientific careers and an increased reliance on foreign nationals—who were unable to stay in the US—to innovate! While changing US immigration laws may allow some foreign nationals to more easily remain in the US, there simply aren’t enough life sciences jobs left in the US to make it worth their while! In fact, the likelihood of them finding life sciences jobs in their home countries is now greater than it is in the US. In my opinion, the only way to restore American innovation in the life sciences is to convince American students that pursuing scientific careers is worthwhile and that the requisite training for industry jobs is available to them.

Interestingly, after leading with changes to US immigration laws, Lechleiter also suggested that America’s innovation problem could be solved by lowering US corporate tax rates and American companies should not be forced to pay taxes on oversea earnings. Also, he asserted that the US Food and Drug Administration (FDA) should stop putting off decisions or erring on the side of avoiding risk when considering new drug applications. 

This begs the questions, how do lower taxes, no overseas taxes and expedited drug approvals help to spur American innovation when most life sciences R&D is conducted outside of the US?

Until next time...

Good Luck and Good Innovating!!!!!!!!

 

Ranbaxy to Hire 1,500 Marketing and Sales Employees to Boldly Go Where No Indian Pharmaceutical Company Has Gone Before

One economic downturn and it seems as though the pharmaceutical world has been turned upside down! Who would have thought a few years ago that emerging pharmaceutical markets in India and Asia will outpace the US and Western European markets in the very near future (I did but nobody listens to me). To that end, Ranbaxy Laboratories will hire nearly 1,500 marketing executives, expanding its sales team by at least 50%, to spur sales and regain its rank as India’s top drug maker. The recruitment push is among the biggest by an Indian drug maker in recent years.  Ironically, pharma sales reps are still being regularly layed off in the US.

The company plans to hire mostly medical representatives, regional managers and area managers by July to boost sales in the rural markets.  According to a Ranbaxy hiring manager “Ranbaxy is looking at new rural markets and deeper penetration in interior markets.”

Ranbaxy is owned by Japan’s Daiichi Sankyo which employs over 12,000 people in 46 countries.

Industry analysts suggest that Ranbaxy’s aggressive hiring push is a sign that the company is focusing on internal markets which are poised for exponential growth in the next few years. Also, Ranbaxy has had its share of legal and regulatory disputes over patents and generics drugs in the US and Western Europe signaling that the company may be pursuing those markets less aggressively than in the past.

Until next time…

Good Luck and Good Job Hunting!!!!!!!

 

Higher Education: The Next Bubble to Burst?

Amber Johnson of Accredited College Online thought that BioJobBlog readers might be interested in an article that she authored entitled “10 Big Ways that the Recession is Hitting Higher Ed.”  It is an informative piece that might be of interest to high school and undergraduate students and parents who have kids in college.

10 Big Ways the Recession is Hitting Higher Ed

From elementary to college, schools around the nation have felt the recession in many different ways. As the economy sinks, the educational demands rise. Teachers are holding on to dear life for their jobs, students are struggling to pay for college and the states are running out of school funding. But even with all of these economic woes, there are still people eager to teach and happy to learn.

  1. Budget Cuts. Since the beginning of the fiscal year, the U.S. has suffered a 5 percent drop (about $4 billion) from the amount of money state governments apportioned for higher education, according to a U.S. News & World Report article. This is directly affecting universities across the country, who’ve seen larger class sizes, less professors and counselors, as well as canceled courses, which experts say could "threaten the quality of education."
  2. Spike in Tuition. College tuition has been an inevitable hurdle for many students and families for years, but in this recession, it stings that much more. Since 1982, college tuition and fees have increased 439 percent, which is about three times higher than the increase in family incomes, according to an ABC news report. In some cases, tuition increases are the school’s response to more financial aid requests, but these scholarships may not be enough to cover soaring prices.
  3. Decline in Aid. Many states are cutting college financial aid programs when students need it most. An increase in unemployment and financial losses has caused 620,000 more students to apply for federal aid in the first quarter compared to last year. An Associated Press article reports that without financial assistance, students may be forced to drop out, transfer or be laden with debt.
  4. Decline in Endowments. A major factor in these educational downturns is the decline in college endowments. Big and small donors simply aren’t giving back right now, which has caused hiring freezes, cutbacks on financial aid and halted construction projects, according to a Wall Street Journal article.
  5. Graduate in Three Years.Graduating in three years is a surefire way to slash college costs. American colleges are now starting to offer three-year college degrees, which is the normal time frame for many British and Canadian students. It’s an upcoming trend, according to CBS MoneyWatch, that could make "elite education" more affordable.
  6. More Kids Are Going Public. According to a CBS News report, private school enrollments have declined as many students make the switch from private to public schools. While some continue to pay top dollar for private school tuition payments, others have had to transfer to less prestigious schools to save money.
  7. Arts Programs Suffer. With devastating budget cuts on the agenda, college art departments are the first area to be altered. According to a New York Times article, students can expect to see fewer teachers, programs and courses in the arts when they return to campus in the fall. While some colleges are phasing out programs altogether, others, like Louisiana State University, are holding off on new computers, production technology and traveling for conferences to lessen their demand for funding.
  8. Growth and Decline of Majors. For college students, choosing the right major during the recession may secure a stable career in the future. Certain industries, such as journalism, entertainment and finance should be avoided, according to a report by College Finance 101, because they have seen the most turmoil during the recession.
  9. Higher Community College Enrollment. With the recession at its peak, many college students have opted for the more affordable institutions — community colleges, according to The Chronicle of Higher Education. However, this influx of students has caused some community colleges to turn them away, claiming there’s not enough room, teachers and accommodations at these campuses.
  10. Distance Learning is More Desirable. A big thing hitting the economy is online education. Whether people have lost a job, are fearful of losing one or want a degree, online colleges have open seats. A CNN report, titled "Riding out the recession in a virtual classroom," touches on the idea of investing in education during troubled times to have a back-up plan and find the right career path for you.

 

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"Breaking Bad"and the American Public's Perception of Scientists

Mention the word “scientist” to most people and they will likely conjure up an image of a socially-inept, nerdy individual who cannot talk to “normal everyday folks” because they are either “too smart” or out of touch with the “real world.” I have been fighting that stereotype for as long as I can remember. I believe that, along the way, I have convinced a few people otherwise and hope that they have learned that “one size does not fit for all scientists”—or any other professional group for that matter. The public perception of scientists was improving until George W Bush, an inveterate anti-science and anti-intellectual advocate became President in 2001. I hope that America’s attitude toward science (and scientists) will change over the next four years as President Obama tries to “restore science to its rightful place.” Nevertheless, I felt compelled to write this post after reading a New York Times review of a television drama called “Breaking Bad” (AMC, Sundays, 10 EDT) which, in my opinion, reinforces the negative stereotypes of scientists held by many members of the lay public.

Breaking Bad centers on a former Caltech chemistry genius named Walt, who failed to live up to the legend of his graduate school days. At 50, he is teaching high school chemistry in Albuquerque, NM. Although he contributed to work of a Nobel-winning team, the teaching job in New Mexico is inexplicably the best that he can get. To make matters worse, his best friend at Cal Tech has amassed a fortune (based largely on Walt’s graduate school work) and is married to Walt’s beautiful ex-wife. Walt learns  after attending a lavish party thrown by his friend, that most of his graduate school classmates (unlike him) are famous world class scientists who live in big homes and make enough money to purchase guitars that previously belonged to Eric Clapton. On top of his devastating psychic and emotional pain, Walt is also suffering from stage 3A lung cancer—even though he never smoked! To save his life, Walt partners with one of his former high school students in the crystal methamphetamine business. Walt’s chemical genius allows him to synthesize the meth from scratch—unlike his scientifically-challenged competitors who must extract the starting materials from over the counter cold remedies—earning him the reputation as one of the best meth ‘cookers” in the US. Walt uses the drug money to pay for his chemotherapy to stay alive and care for 15 year old son with cerebral palsy.  

While the show sounds intriguing, and by all accounts is well acted and provides a glimpse into the lives of people struggling with chronic illness and unrealized career aspirations, it sends the wrong messages to the American public about scientists, their motivations and their lives. First, it portrays Walt’s classmates as wealthy, elitist dilettantes who live lavish lives and don’t think twice about flaunting their status and power as world class scientists. Aside from Craig Venter and several other high profile scientists who are sometimes featured on 60 Minutes, I don’t think that there are many scientists who enjoy the luxurious and opulent lifestyles depicted in Breaking Bad. To the contrary, I suspect that the vast majority of us are struggling, like others, to make ends meet to put food on the table. And, perhaps more importantly, I don’t think that money, fame and fortune induced most of us to become scientists in the first place. Portraying scientists as ego-maniacal, thoughtless, self-absorbed dilettantes sends the wrong message to an American public that is already suspicious and distrustful of science.

Second, Walt’ colleagues view him as a “failed scientist” who, despite his brilliance, has been humiliated and reduced to teaching chemistry (at a low wage) to high school students. Listen to an exchange between Walt and his oncologist “I am an extremely overqualified high school chemistry teacher. When I can work I make $43,700 per year. I have watched all of my colleagues and friends surpass me in every way imaginable....” Unfortunately, Walt’s view of himself—as a lowly, underpaid high school chemistry teacher —is consistent with the attitudes of many academicians who feel that teaching is far less important or valuable than laboratory research. In my previous life as a medical school faculty member, it wasn’t uncommon to see a prominent researcher cringe or shake his/her head in disbelief at the mere mention of a teaching career by a graduate student or postdoctoral fellow. I contend that we ought to encourage (and not dissuade) some of our best and brightest students to pursue teaching instead of research careers. Further, academic researchers must begin to recognize that PhDs who choose to pursue careers in teaching are not less competent or failed scientists—they are simply individuals who want to teach! Given the 20-year long decline in American science and technology preparedness, the scientific community can no longer afford to continue to exclusively promote research over careers in teaching and education.

Finally, the American public has long been suspicious and distrustful of science. In support of this, scientists are often portrayed in literature, movies and in the news as dark, and sometimes mad people who, when left unchecked, will unleash scientific “horrors” on the world.  I am old enough to remember the public fears about the secret bio-warfare programs in the Soviet Union and US during the cold war and more recently, the rumor that was circulating after the HIV/AIDS epidemic was disclosed, that the virus was created by the US government. The brouhaha that erupted over genetic engineering in the 1980s and continued suspicions surrounded genetically modified foods and human cloning are other examples of the public’s distrust of science. Sadly, the decision of the Breaking Bad’s creators to turn Walt, whose chemistry brilliance is unrivaled, into a crystal meth cooker perpetuates the myth about “evil misguided scientists” who are willing to jeopardize the safety of others for their own motives or self gain. The creators of Breaking Bad want us to believe that Walt is justified in turning to the dark side because his power hungry, egomaniacal, scientific colleagues have derailed his career and forced him to become an overqualified, underpaid chemistry teacher. In other words, he had no choice but to use his scientific talents to survive, and perhaps, more importantly, prove to his colleagues (and himself) that he truly is a gifted chemist and not a failed scientist.

Admittedly, while the plot line of Breaking Bad is a little over the top, it tends to reinforce the public’s negative perceptions of scientists and does little to assuage suspicions about the dark underside of modern science.  Like most other people, we scientists are human and have made our share of mistakes. Nevertheless, I think that we  must challenge ourselves to make an effort to educate the American public about who we are and what scientists do on a day to day basis.  If we fail to meet this challenge, I think that President Obama will continue to struggle to “restore science to its rightful place in America.”

Until next time...

 

Good Luck and Good Job Hunting (try public education-schools are hiring!)

 

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