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Ed Silverman, over at the newly reinvigorated Pharmalot Blog, today reported that a recent study publicized in the Journal of the American Medical Association showed that, after a decade of doubling, the rate of increase in biomedical research funding slowed from 2003 to 2007, and after adjusted for inflation, the absolute level of funding from the National Institutes of Health and industry appears to have decreased by 2 percent. The NIH remains the largest federal contributor to biomedicalresearch, accounting for 84% of total federal funding in 2007 

Further, the report indicated that research funding provided by pharmaceutical and biotechnology companies and medical devices and diagnostics manufacturers rose from $40 billion in 2003 to $58.6 billion in 2007; an increase (adjusted for inflation) of roughly 25 percent. Most of the funding came from large pharmaceutical companies. Interestingly, however, the sector of the life sciences industry that exhibited the greatest increase in growth over the same period was diagnostic and device makers (59 percent), followed by biotechnology (41 per cent) and lastly, pharmaceutical companies (25 per cent).

While the results of the study are not surprising, it is clear that the life science sector is beginning to focus more on device and diagnostics than on small molecules and even biotechnology products. Further, reductions in federal funding are forcing researchers to increasingly rely on grants and contracts from private sector companies. This suggests that an ever expanding percentage of the research conducted at many academic institutions will be financed and underwritten by for profit companies. Although more product-focused academic research is not necessarily a bad idea, it does call into question the direction and possible breadth of academic research and the availability and sharing of important scientific information, data sets and discoveries. 

Until next time...

Good Luck and Good Grant Writing!!!!!!!!!

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The competition for National Institutes of Health (NIH) grant funding has been intensifying over the past five years or more. In the past, NIH had gone to extraordinary lengths to insure that senior investigators didn’t lose their funding so as to not hinder the progress of long standing research programs. However, in recent years, NIH funding managers have eschewed the unwritten policy of preferentially funding established investigators in favor of younger ones!  According to an article in today’s New York Times, NIH grant managers are increasingly ignoring the advice of study sections and funding scientists whose projects receive less favorable reviews than those denied money. Many of the favored funding recipients are “new investigators,” or scientists who had never before received a grant from NIH. Further, in 2007, the last year for which figures are available, “19 percent of the grants awarded to individual scientists were made as exceptions, or given outside of rankings by scientific reviewers, according to a report by the Government Accountability Office. Nearly all of the increase in exceptions in 2007 went to new investigators, with the young scientists’ share rising from 20 percent of all exceptions in 2003 to half in 2007.”

Not surprisingly, many senior investigators are calling “foul” despite the fact that the median age at which scientists win their first NIH grant has risen steadily, to 41 years, from 35 in 1980. While all meritorious grant proposals ought to be funded, the reality is that there simply isn’t enough money to around. As a former tenure track faculty member, I believe that new investigators deserve something of a handicap or edge when it comes to competing for their first grants. After all, how can an overwhelmed, newly minted faculty member be expected to successfully compete with established investigators who have mastered their jobs and more importantly, the art of grant writing? Sadly, the old practice of preferentially funding established investigators over new ones tended to stifle innovation and reward scientists who liked to play it safe!

We live in an increasingly competitive world where innovation is at a premium. American scientists and granting agencies must abandon their old practices if they want to remain competitive on the world stage. To that end, funding some young, innovative investigators over a few established faculty members who have enjoyed long successful scientific careers doesn’t seem like a bad investment to me! After all isn’t all about retun on investment these days?

Until next time...

Good Luck and Good Job Hunting!!!!

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For the past 60 years, American science was second to none. However, the US is perilously close to losing that distinction. Put simply, American science, like its economy, is in free fall.

Federal funding, primarily through the National Institutes of Health (NIH), is the lifeblood of American life sciences research. Between 1998 and 2003, the federal government doubled NIH’s budget every year—almost 25% of all grant applications were funded and life was good! However, since 2003, budget increases have vanished and the NIH remains trapped in a five year run of flat funding. Research funding rates have fallen to 10% or less and many academic scientists are voluntarily leaving or being forced out of their jobs.

This is not the first time that funding levels have plummeted. From 1989 to about 1994 (when I was a tenure track Assistant Professor), funding rates fell from about 20% to less than 10%. However, back then, there was little global research competition and American was able to recover to retain its scientific dominance. However, the world is a very different place now and the supremacy of American science, particularly in the life sciences, is clearly at risk.

According to an article in the Trenton Times, (my local paper), science and engineering have accounted for close to half of the growth in the American economy since World War II. Analysts suggest that without adequate research funding and ready access to research grants fewer scientists will enter the profession. “Already Asian countries are graduating 10 times the number of scientists and engineers as the United States. If the current trends continue in about a decade 90% of the world’s scientists and engineers will be in Asia” According to Elias Zerhouni, current director of NIH “In 10 to 15 years we’ll have scientists older than 65 than those younger than 35. This is not a sustainable trend in biomedical research.” Unless federal funding for research is increased this ominous trend will continue. That said, it may be too little too late. As you all know, finding science jobs in the US these days is becoming increasingly difficult even for qualified applicants. With this in mind, one of the most well attended talks that I give at career development symposia is entitled “The Road Less Traveled: Alternate Career Paths for Life Scientists”. As much as I hate to admit it, traditional career pathways for most life scientists may be things of the past.

Clearly, something must be done to fix the problem in order to maintain the quality of American science. The easy fix, which has been used ad nauseam for the pasts two decades, is to increase short term federal research spending. However, history indicates that this approach fosters the boom and bust cycles that have continually plagued American academic science. Although the boom and bust approach is quintessentially American, I don’t think that it will enable American science to sustain its scientific dominance in today’s increasingly competitive world.

The number of young people interested in or entering science continues to plummet in the US. Ironically, the quality and access to American science education has never been better! So, why the disconnect? It’s simple—science jobs are scare, the pay is not great and life as an academician has become almost unsustainable. In my opinion, something has to change very soon or America will almost certainly lose its status as the preeminent purveyor of science in the world.

Until next time,

Good Luck and Good Job Hunting!!!!

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