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While I don’t advocate postdoctoral positions for individuals unless they plan on doing bench science for the rest of their lives, postdoctoral training is a fact of life for those interested in pursuing academic careers. To that end, The Scientist.com conducts an annual survey that ranks the best 40 places for postdoctoral associates to work. The survey ranks the strengths and weaknesses of individual training institutions based on funding, facilities and infrastructure, benefits, training and mentoring and family and personal life. Surprisingly, institutions are also ranked on networking, career development and mentoring and training and mentor and training that they offer to their postdoctoral trainees.

The institution that snagged the top spot on the 2010 list was the Trudeau Institute in Saranac Lake, NY. Nestled in the Adirondack Mountains in Upstate NY, the not-for-profit Trudeau Institute has a deserved international reputation in immunology, infectious diseases and vaccinology. When I was a graduate students (back in the dark ages), some of the greatest minds in infectious diseases held positions at Trudeau. These days; not so much—but I bet the skiing is great! Interestingly, one of Trudeau’s strengths is networking opportunities (how much networking can take place at a secluded institute on a lake in the Adirondacks). Curiously, however, one of its major weaknesses is the lack of career development opportunities. Based on my life experiences, I always thought that networking was a crucial part of career development. But then again, what do I know?

The top 10 of the list featured a couple of Massachusetts-based institutions including the Whitehead Institute for Biomedical Research (3) and the Novartis Institute for Biomedical Research Institute in Cambridge (4) and Woods Hole Oceanographic Institute in Woods Hole, MA (9). Two national laboratories, Sandia National Laboratories, Livermore, CA (8) and Rocky Mountain Laboratory, NIH Hamilton, MT (6) cracked the top ten. By all accounts, the fly fishing is outstanding in Hamilton.

As usual, there were some surprises. These included Samuel Robert Noble Foundation (2) in Ardmore, OK, the University of Colorado, Denver (7) and the Mayo Clinic (10) in Rochester, MN (not exactly cities on my top ten list). Not surprisingly, there were only two life sciences companies that made the Top 40 list; Genentech (5) in South San Francisco and as mentioned above at number 3, the Novartis Institute for Biomedical Research. Once a mainstay, industrial postdocs are becoming increasingly scare and difficult to land. In many cases, these positions are not advertised and generally filled by word-of-mouth recommendations to principal investigators who are looking for postdoctoral fellows.

A quick perusal of the list revealed, as expected, that most of the 40 institutions excelled in categories that included funding, facilities and infrastructure, benefits and family and personal life. In marked contrast, many of the institutions on the list were disappointingly weak in the areas of networking, career development and training and mentoring. Of the top 40, six got kudos for networking (15%), 11 for career development (28%) and only 6 for training and mentoring (15%). These abysmal statistics are somewhat shocking given that postdoctoral fellowships are mainly intended to train and prepare aspiring individuals for lifelong careers as scientists. The fact that only 25% of the nation’s best places to perform postdoctoral research offer career development training and support for postdoctoral trainees suggests that the future of the American life sciences industry may be in serious jeopardy!

Hat tip Ed at Pharmalot.

Until next time....

Good Luck and Good Job Hunting!!!!!!!

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People frequently ask me why I decided to get a PhD degree to become a scientist. For the past 30 years, I have tried to explain to people why I decided to spend seven long years of “blood, sweat and tears” to attain that elusive degree. While anyone who has earned a PhD degree understands what drove them to do it, it is difficult to explain to others that the decision has little to do with career paths and salary considerations and is largely driven by passion— and perhaps more aptly—obsession. That is why Carole and Richard Rifkin’s film “Naturally Obsessed: The Making of Scientist”—an emotional and gritty film that follows the lives of three Columbia graduate students on their quest to obtaining their PhD degrees—is resonating with scientists, students and the public.

The film, which took five years to make and was launched in March 2009, follows the progress of three X-ray crystallography graduate students, Rob, Killington (Kil) and Gabrielle, who worked in Larry Shapiro’s laboratory at Columbia University Medical Center. Work in Larry’s laboratory focuses on elucidating the X-crystallographic structure of proteins that are thought to be involved in appetite control. While Rob, Kil and Gabrielle share a common goal—getting a PhD degree—they are very different people. Rob is a rebellious, boisterous, self-assured free thinker (who was thrown out of a previous laboratory) whereas Kil is a more staid, soft spoken pragmatist from the Midwest. Gabrielle, who returned to graduate school to pursue a PhD degree after a stint as a laboratory technician at a company, loves science but isn’t certain that she has the mettle to realize her dream. Each of them understands that time is of the essence and they work feverishly and unrelentingly  to insure that their competitors don't beat them to the punch and publish first!

Despite their obvious personality differences, each is driven and obsessed with producing perfectly-formed protein crystals that are suitable for X-ray crystallography analysis. The film accurately and painstakingly depicts the inevitable emotional “ups and downs” of laboratory research, the personal struggles and the often difficult life decisions that are made when pursuing a PhD degree. In the end, Rob, Kil and Laura find their own career paths as scientists and perhaps, more importantly. come to terms with the decisions that they made during their journeys.

Carole, a documentary filmmaker, and Richard, Chairman Emeritus of the Sloan-Kettering Institute and founding Chairman of the New York Structural Biology Center, made the film to portray the “reality of doing science” and raise awareness about scientific research. The film emphasizes that science, like art, requires creativity, persistence and unyielding commitment and dedication. The Rifkinds interviewed many NYC-based academic laboratories before choosing Larry Shapiro’s laboratory as the subject of their documentary film. Larry’s laboratory was chosen because X-crystallography is visual (and lends itself to film making) and Carol had a hunch that “there was a story to be told there.”

During a recent interview with the Rifkinds, I mentioned that if I had seen the film as a high school or undergraduate student, I probably would have skipped graduate school. Carole responded and said, “Yes, the hard work and emotional challenges portrayed in the film might turn some students off but we wanted to portray scientific research the way it is and remain true to its realities.” She added, "while the film focuses on science graduate students it is also relevant and accurately reflects the trials and tribulations experienced by PhD students in the humanities and the arts.” 

One of the more troubling moments of the film for me is when Larry mentions that scientists, like artists, “represent the fringe of society.” The fact that a prominent, successful scientist views himself as different, and on the fringes of society, doesn’t bode well for the public perception of science or scientists for that matter. Another troubling aspect of the film is that Rob, Kil and Gabrielle are clearly being groomed for academic careers despite the fact that roughly only 10% of life sciences PhDs secure academic positions at the end of their training. I pointed this out to Richard and he said that he agrees that it is a troubling trend and that “alternate career options for PhDs is the subject of Carole's  and his next film.”

Since it launch in March, the film has been screened at over 60 high schools, colleges, medical schools, professional science associations, government agencies and biotechnology companies. While the film may not be “right” for everyone, it is a must see for graduate students and postdoctoral fellows and for members of the public who want a rare glimpse into the emotionally-charged and highly competitive world of scientific research. For those of you, who may be interested in arranging a screening, please visit the Naturally Obsessed: The Making of a Scientist website or contact Hayley

Until next time....

Good Luck and Good Job Hunting!!!!

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After yesterday's post about career planning for life scientists, one of my soon to be former students in the Fundamentals of Bioscience Program aptly pointed out that my readers might have benefitted more if I had, in fact, offered information about alternate career possibilities for bioscientists.  I don't want the student to get too overconfident but I had the same thought immediately after I uploaded the post.  

Rather than modify the previous post, I decided to upload the presentation that I gave to the U Penn Graduate Student Biomedical Association yesterday.  However, as many of my former (or soon to be former) students will tell you, my PowerPoint presentations, while informative, are not as complete as you might think.  To get the real skinny on alternate careers, you will have to attend one of my seminars on the topic where I provide attendees with additional pearls of wisdom and some funny stories about my own journey along an oft times circuitous career path!

Until next time.....

Good Luck and Good Job Hunting

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Yesterday, I gave a lecture entitled “Alternate Careers: Taking the Road Less Traveled” to over 100 members of the University of Pennsylvania’s Biomedical Graduate Student Association. As always, there were many good questions and comments during and after the presentation. Some of the career anecdotes offered by several of the students reminded me of a conversation that I had several weeks ago with one of my Fundamentals of Bioscience students—I teach a Product Development and Regulatory Affairs course in the program—who refreshed my memory about a typical graduate student approach to career development and job searching. “We don’t think about jobs or our careers until we begin writing our PhD theses” she said. “Until then, our advisers don’t talk about careers or jobs and only bring it up because our funding will run out” she added. Admittedly, I had forgotten this because so many years have passed since my graduate student days. That said, it forced me to consider how much the life sciences job market has changed since I was graduate student and how vitally important it is for today’s graduate students to think about and possibly explore different career options throughout the course of their graduate training.

Historically, there were very few career options for life scientists—it was either a tenure track faculty appointment or, as a poor second choice, a job at a pharmaceutical or biotechnology. Unfortunately, academics jobs are hard to come by and since 2007 over 60,000 pharmaceutical R&D scientists have lost their jobs and more cuts are expected. Also, many of these jobs are likely come back after the economy improves because many of the R&D activities performed by these scientists are being outsourced to India, China and elsewhere. This suggests that a majority of life sciences graduate students who receive their PhDs within the next few years won’t be able to secure traditional life sciences jobs. While a majority of US life sciences graduate training programs recognize and understand the implications of the changing job market, many are reluctant to discuss alternate career options with graduate students and postdoctoral fellows. Even fewer, encourage or support students or postdoctoral fellows who want to engage in “extracurricular activities” to explore alternate career options. In fact, several U Penn students told me that they have to obtain written permission from their adviser before they can take courses or participate in extra-departmental activities. As one student quipped “What I do on my own time should be my business not my boss's.”

I always conclude my alternate career talk by saying “Nobody ever guaranteed you a job after completion of your PhD or postdoctoral training.” And, “if you wanted a job after completing your education, you ought to have gone to medical school, dental school, law school or any other profession that requires licensure to practice your craft.” While this may sound harsh, I believe that the decision to get a PhD is a personal one and based on discussion with many of my colleagues, most didn’t enter graduate school expecting a job to be waiting them when they completed their training. Nevertheless, I contend that graduate departments that continue to train and prepare students for traditional academic careers —knowing that over 90% won’t find jobs (other than postdocs) after their training is finished —are being disingenuous and even deceitful. Why haven’t academician realized that there is a plethora of job opportunities for life scientists outside of academia?

Like it or not, the life sciences job market has undergone radical changes in the past decade. Unfortunately, academics continue to adhere to dogmatic and anachronistic ideas and practices that don’t prepare their students and postdoctoral fellows for jobs in “the real world.” I contend that informing and enlightening graduate students about alternate career paths and, allowing them to explore some of these opportunities will not impede or hinder laboratory research. Instead, I believe it would help to improve and expedite its progress. As one U Penn graduate student shared with me over a couple of beers “If they would just tell us the truth and give us some idea about our options, it would certainly improve morale, reduce our anxiety and allow us to focus on our research because we would know what is out there!” As the old adage goes”ignorance is bliss.” But, in my experience, knowledge is power!

Until next time....

Good Luck and Good Job Hunting!!!!!!!!!!

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After months of complaints by university officials and scientific organizations, the US State Department announced on Tuesday that it is taking action to speed up the delay-plagued visa process for foreign graduate students and post-doctoral researchers.

For the past few years, foreign science and engineering graduate students and postdoctoral seeking to obtain or renew visas have routinely experienced long delays sometimes taking as long as several months. The problem became so acute that students and researchers who left the US often found themselves stranded abroad, not knowing when their visas might be approved.  Not surprisingly, the delays have caused enormous problems for American universities, which heavily rely on foreign nationals to fill slots in graduate and post-doctoral science and engineering programs. Over the last year or so, visa difficulties having discouraged many scientific organizations from holding meetings in the United States. Some life sciences researchers said the apparent reluctance of the United States to accept them encouraged them to seek work in other countries.

The State Department has hired additional personal to deal with the visa backlog but will not say how long it will take to correct the problem. A state department official indicated that they hope to handle routine visa requests within a two week time frame.

While never officially acknowledged, the Bush Administration intentionally slowed the visa process for foreign researchers to “guard against proliferation of science and technical information.” In other words, the visa backlog was likely intentionally created to prevent foreign drug companies and national scientific agencies from infringing on American intellectual property and patent rights—an ongoing practice that clearly frightened many of the jingoistic officials running the Bush State Department.

However, what the Bush administration failed to understand was that a majority of foreign students who train in the US want to remain here after completion of their studies. The visa backlog and its protectionist intent forced many foreign nationals to forgo their US training and return to their home countries to seek employment. This was beginning to threaten scientific and technical innovation in US laboratories because for the past decade or longer American students have shied away from science and engineering to pursue careers in business and computer science. Ironically, the Bush Administration’s protectionist leanings may have contributed—more than they care to admit—

 to the massive job cuts that have taken place at American life sciences companies in the past few years because of availability of a US-trained work forces in countries like India and China. This provides American life sciences companies with reasonable assurances that preclinical and clinical research outsourced to these countries will be conducted according to US standards. Further, it also provides foreign companies with unbridled access to a growing cadre of US-trained scientists that will enable them to compete on a head-to-head basis with American life sciences companies.

Fortunately, the Obama Administration, unlike the previous one, delivers on its promises and appears to be willing to work hard to restore science and technology to its rightful place in American society.

Until next time...

Good Luck and Good Job Hunting (it may now be possible for many foreign students!)

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Over the past several years, I have publicly called for fundamental changes in graduate education and training for life scientists. To that end, I was delighted to read an OP-ED piece in today’s New York Times entitled “End Universities as We Know It” written by Professor Mark C. Taylor, Chairperson of the religion department at Columbia University. 

In his post, Professor Taylor recommended several fundamental and systemic changes that ought to improve the likelihood that graduate students and postdoctoral fellows find jobs at the end of their graduate education. While some of Dr. Taylor’s ideas are novel and innovative, two in particular; 1) expanding the range of career opportunities for graduate students and postdocs and 2) abolishing tenure and mandatory retirement; are ones that I have suggested many times in the past few years. Rather than paraphrase, I decided to repost what Dr Taylor said about these two very important, seminal issues.

Expand the range of professional options for graduate students

Most graduate students will never hold the kind of job for which they are being trained. It is, therefore, necessary to help them prepare for work in fields other than higher education. The exposure to new approaches and different cultures and the consideration of real-life issues will prepare students for jobs at businesses and nonprofit organizations. Moreover, the knowledge and skills they will cultivate in the new universities will enable them to adapt to a constantly changing world.

Impose mandatory retirement and abolish tenure

Initially intended to protect academic freedom, tenure has resulted in institutions with little turnover and professors impervious to change. After all, once tenure has been granted, there is no leverage to encourage a professor to continue to develop professionally or to require him or her to assume responsibilities like administration and student advising. Tenure should be replaced with seven-year contracts, which, like the programs in which faculty teach, can be terminated or renewed. This policy would enable colleges and universities to reward researchers, scholars and teachers who continue to evolve and remain productive while also making room for young people with new ideas and skills.

For many years now, I have been struggling with the moral and ethical obligations of graduate education. Recently, I came to the conclusion that it is our role as educators to selflessly impart knowledge and training to graduate students and postdoctoral fellows so that they can pursue the careers (and lives) that many have trained for a decade or more. I think Professor Taylor’s view of the role of an educator says it best: “Do not do what I do; rather, take whatever I have to offer and do with it what I could never imagine doing and then come back and tell me about it.” This is the attitude that must be by academicians if America wants to remain competitive in the life sciences.

Until next time....

Good Luck and Good Job Hunting!!!!!!!!

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For the past five years, I have been giving career development seminars that offer graduate students and postdoctoral fellows alternate careers choices (instead of research) for life scientists. The intent of these seminars is to get students who may not be enamored with a possible life long career at the bench (I know that there a lot of you out there) to think about what they really want to do after they complete their graduate or postdoctoral training.

I recently met Jane Chin (on Twitter) who, like me, has had an unorthodox career trajectory for a life scientist. After exchanging several tweets, I learned that we both are microbiologists, Cornell University graduates, entrepreneurs and social media enthusiasts. But, the main reason I am telling you about Jane is that she crafted a fascinating PowerPoint presentation entitled “3 Lessons About Career Life From a Career Nomad” that provides insights into the decisions and choices that she made to shape her current career path. I highly recommend that you take a peek at the presentation—it may help to reduce some future career stress and angst!

Until next time…

Good Luck and Good Job Hunting!!!!!!

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I want to let my readers know that a beta-version of BioCrowd is ready for review. For those of you who may not know about BioCrowd, it is a social network for life sciences students and professionals that was created by Vincent Racaniello a Professor at Columbia University College of Physicians and Surgeons and me. 

The reason we started BioCrowd was that Vincent and I both perceived a need for undergraduate and graduate students and postdoctoral fellows to more effectively network with established scientists and life sciences professionals to further advance their careers or find jobs. The social interactivity of Facebook and the business connectivity of LinkedIn are what led to the creation of BioCrowd.

We are looking for a few brave women and men who want to help to beta-test BioCrowd before we launch.  If you are interested, please visit us at www.biocrowd.com and drop us a line.   For those of you who don't want to participate at the moment, but want to learn about our progress, you can follow us on Twitter and FriendFeed ,

Until next time...

Good Luck and Good Job Hunting!!!!!!!

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Yes, even the Ivy League isn’t immune to food poisoning outbreaks from time-to-time. There are currently 10 confirmed cases of Salmonella food poisoning at Princeton U. Another 50 people or so have also fallen ill with gastrointestinal symptoms consistent with Salmonella food poisoning.  As a precaution, university officials have temporarily discontinued doing business with their produce suppliers. For those of you who don’t know, Princeton is famous (infamous?) for its so-called dining clubs. These clubs take the place of sororities and fraternities which are not allowed at this august institution of higher education. Obviously, there is more than eating that goes on at these “dining clubs.”

The reason I am blogging about the outbreak is two-fold. First, I live about seven miles from Princeton and it has been all over the local news. Second, I did my PhD work on the pathogenesis of Salmonella gastroenteritis. So, Salmonella food poisoning is dear to my heart (thankfully, not my gastrointestinal tract). Many infectious disease experts tend to dismiss the seriousness of Salmonella gastroenteritis. This is likely because it is usually not as devastating as shigellosis or infections caused by enteroinvasive strains of Escherichia coli (which is actually Shigella masquerading as E. coli). As my major professor once put it “You know when you have Salmonella gastroenteritis—if you can’t decide than it is not salmonellosis.”

I am happy to report that I never came down with gastroenteritis while working for over three years with enteroinvasive Salmonella strains (even though I was routinely mouth pipetting and eating lunch in the lab; practices which aren’t acceptable by today’s standards). I like to think that “the bugs” were afraid of me. Alternatively I had either a great immune system or extremely good aseptic techniques. Whatever the reason, it is always embarrassing when card-carrying microbiologists come down with the disease(s) that they are studying. Luckily, I never came down with the disease caused by the bacterium that I was studying during my first postdoctoral fellowship—Neisseria gonorrhoeae. That would have been extremely difficult to explain!

Until next time…

Good Luck and Good Job Hunting (remember to wash your hands)!!!!!!!!

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