Film Review: "Naturally Obsessed: The Making of a Scientist"

People frequently ask me why I decided to get a PhD degree to become a scientist. For the past 30 years, I have tried to explain to people why I decided to spend seven long years of “blood, sweat and tears” to attain that elusive degree. While anyone who has earned a PhD degree understands what drove them to do it, it is difficult to explain to others that the decision has little to do with career paths and salary considerations and is largely driven by passion— and perhaps more aptly—obsession. That is why Carole and Richard Rifkin’s film “Naturally Obsessed: The Making of Scientist”—an emotional and gritty film that follows the lives of three Columbia graduate students on their quest to obtaining their PhD degrees—is resonating with scientists, students and the public.

The film, which took five years to make and was launched in March 2009, follows the progress of three X-ray crystallography graduate students, Rob, Killington (Kil) and Gabrielle, who worked in Larry Shapiro’s laboratory at Columbia University Medical Center. Work in Larry’s laboratory focuses on elucidating the X-crystallographic structure of proteins that are thought to be involved in appetite control. While Rob, Kil and Gabrielle share a common goal—getting a PhD degree—they are very different people. Rob is a rebellious, boisterous, self-assured free thinker (who was thrown out of a previous laboratory) whereas Kil is a more staid, soft spoken pragmatist from the Midwest. Gabrielle, who returned to graduate school to pursue a PhD degree after a stint as a laboratory technician at a company, loves science but isn’t certain that she has the mettle to realize her dream. Each of them understands that time is of the essence and they work feverishly and unrelentingly  to insure that their competitors don't beat them to the punch and publish first!

Despite their obvious personality differences, each is driven and obsessed with producing perfectly-formed protein crystals that are suitable for X-ray crystallography analysis. The film accurately and painstakingly depicts the inevitable emotional “ups and downs” of laboratory research, the personal struggles and the often difficult life decisions that are made when pursuing a PhD degree. In the end, Rob, Kil and Laura find their own career paths as scientists and perhaps, more importantly. come to terms with the decisions that they made during their journeys.

Carole, a documentary filmmaker, and Richard, Chairman Emeritus of the Sloan-Kettering Institute and founding Chairman of the New York Structural Biology Center, made the film to portray the “reality of doing science” and raise awareness about scientific research. The film emphasizes that science, like art, requires creativity, persistence and unyielding commitment and dedication. The Rifkinds interviewed many NYC-based academic laboratories before choosing Larry Shapiro’s laboratory as the subject of their documentary film. Larry’s laboratory was chosen because X-crystallography is visual (and lends itself to film making) and Carol had a hunch that “there was a story to be told there.”

During a recent interview with the Rifkinds, I mentioned that if I had seen the film as a high school or undergraduate student, I probably would have skipped graduate school. Carole responded and said, “Yes, the hard work and emotional challenges portrayed in the film might turn some students off but we wanted to portray scientific research the way it is and remain true to its realities.” She added, "while the film focuses on science graduate students it is also relevant and accurately reflects the trials and tribulations experienced by PhD students in the humanities and the arts.” 

One of the more troubling moments of the film for me is when Larry mentions that scientists, like artists, “represent the fringe of society.” The fact that a prominent, successful scientist views himself as different, and on the fringes of society, doesn’t bode well for the public perception of science or scientists for that matter. Another troubling aspect of the film is that Rob, Kil and Gabrielle are clearly being groomed for academic careers despite the fact that roughly only 10% of life sciences PhDs secure academic positions at the end of their training. I pointed this out to Richard and he said that he agrees that it is a troubling trend and that “alternate career options for PhDs is the subject of Carole's  and his next film.”

Since it launch in March, the film has been screened at over 60 high schools, colleges, medical schools, professional science associations, government agencies and biotechnology companies. While the film may not be “right” for everyone, it is a must see for graduate students and postdoctoral fellows and for members of the public who want a rare glimpse into the emotionally-charged and highly competitive world of scientific research. For those of you, who may be interested in arranging a screening, please visit the Naturally Obsessed: The Making of a Scientist website or contact Hayley

Until next time....

Good Luck and Good Job Hunting!!!!

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How to Become a Pharmaceutical Scientist

Last week, I had the great fortune to meet (on the Recruiting Animal Show) a career development expert who despite her young age, has seminal insights into today’s job market and how to break into it. Alexandra Levit, a self-avowed GenXer on the GenY cusp, is the author of several books, including They Don't Teach Corporate in College, How'd You Score That Gig? and Success for Hire.

In addition to her book writing activities, Alex’s career advice posts are featured monthly in the Huffington Post and have been showcased in more than 800 media outlets including ABC News, the Associated Press, USA Today, the Wall Street Journal, the New York Times, National Public Radio, Fortune, Yahoo!, and MSN. She is recognized as one of her generations (X or Y?) preeminent career experts who regularly speak at universities and corporations on workplace issues facing young employees.

Alex and I got to talking after Animal' show and I learned that like me, she dabbles in the pharmaceutical career development arena. That said, she graciously agreed to allow me to post a piece that she wrote entitled “Want to Become a Pharmaceutical Scientist? Here’s How!” (see below) that offers guidance for entry level scientist who are considering careers in the pharmaceutical or biotechnology industries. Read and learn!

"Want to Become a Pharmaceutical Scientist? Here’s How!"

Talk about a career with intriguing possibilities. People entering the pharmaceutical research field today may be the ones discovering the cure for cancer or Parkinson’s disease tomorrow. Although the United States’ pharmaceutical companies sometimes get a bad rap, they routinely make astounding advances that save lives, and from what I hear, aren’t bad places to work either. If you’re a data-head who wants to use your scientific background for the greater good, you might consider becoming a pharmaceutical scientist. Here’s some detail about what breaking into the field entails.

According to the American Association of Pharmaceutical Scientists, the pharmaceutical sciences combine a broad range of scientific disciplines that are critical to the discovery and development of new drugs, therapies, and medical devices. Some of the more common specializations include drug discovery and design, whichdeals with the design and synthesis of new drug molecules and includes medicinal chemistry, combinatorial chemistry, and biotechnology; drug delivery, which is concerned with the design of dosage forms – such as tablets, injections or patches – that deliver the drug to the site of action within a patient; drug action, which examines how the drug works in a living system; clinical pharmacology, which is concerned with the use of drugs in the treatment of diseases and leverages human clinical trials to determine efficacy, adverse effects, and drug-to-drug interaction; and drug analysis, which involves separating, identifying, and quantifying the components of a sample.

Twenty-eight year old Matt, a senior research associate at Novartis, spends his days engaged in both drug action and drug analysis for the company’s wide range of prescription medications for ailments such as heart disease, high blood pressure, and diabetes. He’s responsible for testing animal organ and plasma samples to determine if a drug is working the way it’s supposed to. “It’s my job to quantify the drug’s efficacy in the body, to gather early support as it moves through the process of getting approved by the Food and Drug Administration,” he says. 

While the majority of pharmaceutical scientists are employed by private-sector pharmaceutical companies, others work as researchers and professors at universities, as regulatory scientists for government agencies like the Food and Drug Administration (FDA), or as researchers at national laboratories such as the National Institutes of Health (NIH). An undergraduate degree in chemistry, biology, pharmacy, or engineering is a prerequisite for the entry-level position of research assistant. The research assistant, who receives a broad-based introduction to the pharmaceutical world, records, stores and summarizes information and data, prepares technical reports, and develops laboratory skills and familiarity with equipment. “You should expect that your first job will be low level and the work very routine,” says Matt. “You won’t have much of a chance to be creative or innovative, and you have to be tolerant of that at the beginning of your career.” Adds Beth, 31, an R&D project director at a top pharmaceutical company in the Northeast: “Make the most of each opportunity, no matter how small. Success with smaller projects will directly lead to greater responsibility and rapid professional growth. Focus both on delivering results and on how you deliver the results: for example, through strong teamwork or a rigorous research approach.”

Recent college grads looking for research assistant jobs may want to start by educating themselves about the pharmaceutical industry in general. The Pharmaceutical Research and Manufacturers of America Web site (www.phrma.org) and the American Association of Pharmaceutical Scientists Web site (www.aapspharmaceutica.com) are great places to check out relevant publications, networking events, and internship and employment listings. Specific job opportunities can also be found on industry job portals including www.biospace.com, www.hirerx.com, and www.medzilla.com, and you might also take advantage of openings advertised through your college’s career center. “My first paying job was an internship at a medical device company,” says Beth. “I made the original contact at an MIT career fair and then interviewed on campus with the company’s recruiting team. I shared my passion for medical device engineering and my solid academic background and was hired after my sophomore year.”

Matt also suggests that you might get in the door by connecting with a temporary employment firm specializing in pharmaceuticals. “I signed on with Kelly Scientific right out of school,” he says. “Almost immediately, I got contract work doing clinical research studies that eventually resulted in a full-time job.” Women may find that they’re especially marketable, as the pharmaceutical industry is still predominantly male and most organizations are striving to even things out.

The typical pharmaceutical research career has ample room for growth. From the position of research assistant, you can progress to a research associate, an associate scientist, a scientist, a senior scientist, and a principal scientist. After you’ve reached a certain level, you may also have the option of taking on a cross-functional role in research management, regulatory affairs, pharmacoeconomics, or communications. At the moment, most people who reach the top levels of the profession get a Ph.D. along the way, but many say that’s changing and that experience in the lab is increasingly worth more than formal education. You’ll be happy to learn that compared to other industries, compensation is quite generous. According to a recent American Association for the Advancement of Science Salary Survey, pharmaceutical research assistants make more than $65K with just a bachelor’s degree, and six-figure incomes are standard after a few years.

Like other data-heads, pharmaceutical scientists are highly analytical and have had the math and science coursework to back up their natural talent. “You have to be anal about the details, because one small error can mess up a whole batch of samples,” says Matt. A cool-headed approach to troubleshooting is critical as well. “Development setbacks occur frequently,” says Beth. “When something goes wrong, my first step is to pull the team together to diagnose the situation. I do not try to lay blame but want to ensure that we learn and do not repeat the mistake or ignore the issue as we move forward.” Additionally, pharmaceutical research environments can be political and difficult to navigate at times. “Drug research isn’t always run like a well-oiled machine and loyalty to the company doesn’t always work in your favor,” says Matt. “You have to have a good sense of what you’re worth and what you have to offer.”

If you think pharmaceutical research might be for you, now’s a great time to test drive it as a career. A special supplement on hiring trends in the pharmaceutical space published in The Scientist in 2005 reported that the number of people employed in the U.S. industry is expected to grow from 413,700 to 536,000 in the next decade, and that Research & Development spending, which exploded in 2004, is still steadily increasing. “I love my job because I have the opportunity to impact patients with my daily work, collaborating with my fellow team members to solve complex problems,” says Beth. “And I feel very fortunate to work at a company where my personal values align very closely with the corporate culture.”

Until next time…

Good Luck and Good Job Hunting!!!!!!

Job Security of Life Scientists?

As a self-anointed career development professional, I frequently read blogs and online articles dealing with jobs and career development advice. That said,  I happened upon a piece in Yahoo Education entitled “Risky Business: Finding Job Security in Tough Times”. The article featured careers that may provide greater than average job security to employees. Everything was going great until I read the no. 4 career on the list–Medical Scientist– I kid you not. This is what the author had to say about medical/life scientists:

 “With increases in funding for treating cancer, AIDS, mental illness, and other diseases, corporate pharmaceutical, biotech, and university research labs need more people to develop vaccines and treatment drugs. Depending on your medical specialty, you'll typically need a master's degree or PhD. Often M.D.-holders choose research work over medical practice. You can begin traveling this path by earning a bachelor's degree in a biological science, and focusing on chemistry, biology, statistics, and research methods. Salaries in private sector biotech firms are typically higher than those offered at the college research level. There are also jobs with government medical-research agencies. Median salary range: $44,830 to $88,130.”

I ‘m not sure where the author has been or what she has been smoking but it seems to me that she is not in sync with industry trends. Maybe I ought to write to her and ask her to send me a list of companies that are currently hiring. I guess you really can’t believe everything that you read!

Until next time….

Good Luck and Good Job Hunting!!!!!!!!!!!!!